Burkitt lymphoma

Synonyms: Burkitt's lymphoma; Familial Burkitt's lymphoma

Summary

Burkitt lymphoma is a rare, aggressive B-cell lymphoma that accounts for 30 to 50% of lymphomas in children but only 1 to 2% of lymphomas in adults (Harris and Horning, 2006). It results from chromosomal translocations that involve the MYC gene (190080) and either the lambda or the kappa light chain immunoglobulin genes (147220, 147200). Burkitt lymphoma is causally related to the Epstein-Barr virus (EBV), although the pathogenetic mechanisms are not clear. [from OMIM]

Available tests

11 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (11 available)

Cytogenetics Tests

Molecular Genetics Tests

Genes See tests for all associated and related genes

Associated genes Help
Genes reported to contribute to the condition.

MYC
Also known as: MRTL, MYCC, bHLHe39, c-Myc, MYC
Summary: MYC proto-oncogene, bHLH transcription factor

Imported from Human Phenotype Ontology (HPO)

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Abnormality of the immune system
- Immunodeficiency
  Immunodeficiency
  - MedGen UID: 7034
  - Concept ID: C0021051
  - Finding: Disease or Syndrome
  Abnormality of the immune system
  See: Feature record | Search on this feature
Neoplasm
- Burkitt lymphoma
  Burkitt lymphoma
  - MedGen UID: 2377
  - Concept ID: C0006413
  - Finding: Neoplastic Process
  Neoplasm
  See: Feature record | Search on this feature

Reviews

Clinical resources

Practice guidelines

NCCN, 2024
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024
NCCN, 2024
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Aggressive Mature B-Cell Lymphomas, 2024

Molecular resources

Consumer resources

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