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    TNK2 tyrosine kinase non receptor 2 [ Gallus gallus (chicken) ]

    Gene ID: 431014, updated on 10-Oct-2024

    Summary

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    Symbol
    TNK2provided by CGNC
    Full Name
    tyrosine kinase non receptor 2provided by CGNC
    Primary source
    CGNC:26882
    See related
    Ensembl:ENSGALG00010015146
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TNK2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (14647452..14667074)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (14443420..14463005)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417078 Neighboring gene transferrin receptor Neighboring gene mucin 4, cell surface associated Neighboring gene mucin 4 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activated CDC42 kinase 1
    XP_004943402.2
    XP_015146941.2
    XP_015146942.2
    XP_015146943.2
    XP_015146944.1
    XP_015146945.1
    XP_015146947.1
    XP_025009316.2
    XP_040534575.1
    XP_040534576.1
    XP_040534578.1
    XP_040534579.1
    XP_040534580.1
    XP_040534581.1
    XP_040534582.1
    XP_040534584.1
    XP_046754440.1
    XP_046754441.1
    XP_046780000.1
    XP_046780001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      14647452..14667074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015291459.4 → XP_015146945.1  activated CDC42 kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YK08
      Related
      ENSGALP00010021268.1, ENSGALT00010036519.1
      Conserved Domains (7) summary
      cd09539
      Location:45 → 90
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:413 → 461
      SH3; Src homology 3 domains
      cd14274
      Location:1021 → 1065
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1052 → 1091
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:150 → 407
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:469 → 534
      GTPase_binding; GTPase binding
      pfam11555
      Location:844 → 913
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    2. XM_046898485.1 → XP_046754441.1  activated CDC42 kinase 1 isoform X9

      Related
      ENSGALP00010021258.1, ENSGALT00010036509.1

    3. XM_046898484.1 → XP_046754440.1  activated CDC42 kinase 1 isoform X2

    4. XM_015291461.4 → XP_015146947.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q2UHM8
      Conserved Domains (7) summary
      cd09539
      Location:22 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:390 → 438
      SH3; Src homology 3 domains
      cd14274
      Location:998 → 1042
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1029 → 1068
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:127 → 384
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:446 → 511
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 890
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    5. XM_004943345.5 → XP_004943402.2  activated CDC42 kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YRC9, A0A8V0YY50
      Related
      ENSGALP00010021250.1, ENSGALT00010036497.1
      Conserved Domains (5) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      cd14274
      Location:1120 → 1164
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1151 → 1190
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    6. XM_015291455.4 → XP_015146941.2  activated CDC42 kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (5) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      cd14274
      Location:1095 → 1139
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1126 → 1165
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    7. XM_015291456.4 → XP_015146942.2  activated CDC42 kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YJZ3, A0A8V0YY50
      Related
      ENSGALP00010021253.1, ENSGALT00010036503.1
      Conserved Domains (6) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      PHA03247
      Location:587 → 1040
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1080 → 1124
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1111 → 1150
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    8. XM_015291457.4 → XP_015146943.2  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YT31, A0A8V0YY50
      Related
      ENSGALP00010021256.1, ENSGALT00010036507.1
      Conserved Domains (4) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1055 → 1099
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1086 → 1125
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    9. XM_025153548.3 → XP_025009316.2  activated CDC42 kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (4) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1015 → 1059
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1046 → 1085
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    10. XM_015291458.4 → XP_015146944.1  activated CDC42 kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2UHM8, A0A8V0YRC4
      Related
      ENSGALP00010021245.1, ENSGALT00010036490.1
      Conserved Domains (7) summary
      cd09539
      Location:48 → 93
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:416 → 464
      SH3; Src homology 3 domains
      cd14274
      Location:1024 → 1068
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1055 → 1094
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:153 → 410
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:472 → 537
      GTPase_binding; GTPase binding
      pfam11555
      Location:847 → 916
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      14443420..14463005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040678647.2 → XP_040534581.1  activated CDC42 kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0YK08
      Conserved Domains (7) summary
      cd09539
      Location:45 → 90
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:413 → 461
      SH3; Src homology 3 domains
      cd14274
      Location:1021 → 1065
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1052 → 1091
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:150 → 407
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:469 → 534
      GTPase_binding; GTPase binding
      pfam11555
      Location:844 → 913
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    2. XM_046924045.1 → XP_046780001.1  activated CDC42 kinase 1 isoform X9

    3. XM_046924044.1 → XP_046780000.1  activated CDC42 kinase 1 isoform X2

    4. XM_040678650.2 → XP_040534584.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q2UHM8
      Conserved Domains (7) summary
      cd09539
      Location:22 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:390 → 438
      SH3; Src homology 3 domains
      cd14274
      Location:998 → 1042
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1029 → 1068
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:127 → 384
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:446 → 511
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 890
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

    5. XM_040678641.2 → XP_040534575.1  activated CDC42 kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (5) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      cd14274
      Location:1120 → 1164
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1151 → 1190
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    6. XM_040678642.2 → XP_040534576.1  activated CDC42 kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (5) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      cd14274
      Location:1095 → 1139
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1126 → 1165
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    7. XM_040678644.2 → XP_040534578.1  activated CDC42 kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (6) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:512 → 560
      SH3; Src homology 3 domains
      PHA03247
      Location:587 → 1040
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1080 → 1124
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1111 → 1150
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    8. XM_040678645.2 → XP_040534579.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (4) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:1055 → 1099
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1086 → 1125
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    9. XM_040678648.2 → XP_040534582.1  activated CDC42 kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0YY50
      Conserved Domains (5) summary
      cd09539
      Location:144 → 189
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:546 → 975
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1015 → 1059
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1046 → 1085
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:249 → 506
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    10. XM_040678646.2 → XP_040534580.1  activated CDC42 kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q2UHM8, A0A8V0YRC4
      Conserved Domains (7) summary
      cd09539
      Location:48 → 93
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:416 → 464
      SH3; Src homology 3 domains
      cd14274
      Location:1024 → 1068
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1055 → 1094
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:153 → 410
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:472 → 537
      GTPase_binding; GTPase binding
      pfam11555
      Location:847 → 916
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    Nucleotide Protein
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