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    ZNF136 zinc finger protein 136 [ Homo sapiens (human) ]

    Gene ID: 7695, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF136provided by HGNC
    Official Full Name
    zinc finger protein 136provided by HGNC
    Primary source
    HGNC:HGNC:12920
    See related
    Ensembl:ENSG00000196646 MIM:604078; AllianceGenome:HGNC:12920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pHZ-20
    Summary
    This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.2), ovary (RPKM 4.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF136 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12163096..12189871)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12287953..12318112)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12273911..12300686)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF625-ZNF20 readthrough (NMD candidate) Neighboring gene ribosomal protein L17 pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12267212-12267903 Neighboring gene zinc finger protein 625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14046 Neighboring gene uncharacterized LOC100289333 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:12315316-12315484 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12342780-12343609 Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus. Liu C, et al. Arch Virol, 2014 Apr. PMID 24136724
    2. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing H, et al. FEBS Lett, 1995 Aug 7. PMID 7649249
    3. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
    4. Isolation of cDNA clones for 42 different KrĂĽppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
    5. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Through peptide mass fingerprinting, the hepatitis C virus NS2-interacting protein was found to be homologous to a repressor of transcription, ZNF136.
      Title: A potential cellular host factor homologous to ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis C virus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 136

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052983.1 RefSeqGene

      Range
      5050..31825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348013.2 → NP_001334942.1  zinc finger protein 136 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK299601, AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
      UniProtKB/Swiss-Prot
      P52737
      UniProtKB/TrEMBL
      B4DS70
      Conserved Domains (2) summary
      COG5048
      Location:91 → 460
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001348014.2 → NP_001334943.1  zinc finger protein 136 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon, resulting in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL537987, BC006421, BP420506, BQ574220, CN429121, DA783495, DB369850
      Consensus CDS
      CCDS92526.1
      UniProtKB/TrEMBL
      A0A494C0J2
      Related
      ENSP00000498578.1, ENST00000652580.1
      Conserved Domains (2) summary
      COG5048
      Location:125 → 494
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:222 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_003437.5 → NP_003428.1  zinc finger protein 136 isoform 1

      See identical proteins and their annotated locations for NP_003428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer/longest* isoform (1).
      Source sequence(s)
      AL537987, BC006421, BP420506, BQ574220, CN429121, DB369850
      Consensus CDS
      CCDS32916.1
      UniProtKB/Swiss-Prot
      P52737
      Related
      ENSP00000344162.4, ENST00000343979.6
      Conserved Domains (3) summary
      COG5048
      Location:157 → 526
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 44
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12163096..12189871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12287953..12318112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322009.1 → XP_054177984.1  zinc finger protein 136 isoform X1

      UniProtKB/Swiss-Prot
      P52737
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52737.1 GenPept UniProtKB/Swiss-Prot:P52737

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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