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Conserved domains on  [gi|1126724274|ref|NP_001334943|]
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zinc finger protein 136 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-494 2.69e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 125 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 201
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 202 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 281
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 282 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 358
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 359 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 426
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724274 427 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 494
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-494 2.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 125 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 201
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 202 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 281
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 282 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 358
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 359 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 426
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724274 427 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 494
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-287 7.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....*
gi 1126724274 263 LRIHERTHTGEKPYECKQCGKAFSY 287
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-494 2.69e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 125 THEIIHTGEKLYDC--KECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSHTGE-KPYECQECGKAF 201
Cdd:COG5048    51 RHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 202 TCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQvhERIHTGEKPFKCKQCGKAFScsptLRIHERTHTGEKPYECKQC 281
Cdd:COG5048   131 SSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--SLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 282 GKAFSYLPSLRLHERIHTGEKPFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEG--- 358
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 359 ----PYKCKVCGKPFHSLSPFRIHERT--HTGE--KPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFS 426
Cdd:COG5048   285 gfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126724274 427 YLNSFRTHEMIH-----TGEKPFEC--KRCGKAFRSSSSFRLHERTHTGQKPYHCK--ECGKAYSCRASFQRHMLTH 494
Cdd:COG5048   365 PLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-475 2.55e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 162 TPYKCKVCGKAFDYPSRFRTHERSHTGEKPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHS-LSSFQVH 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 239 ERIHTGEKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLP-SLRLHERIHTGEKPfvckqcgKAFRSAS 317
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 318 TFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPYKCKVCGKPFH----SLSPFRIHERTHTGEKPYVCKHC 393
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 394 G--KAFVSSTSIRIHERTHTG-EKPYECKQCGKAFSYLNSFRTH--EMIHTGE--KPFEC--KRCGKAFRSSSSFRLHER 464
Cdd:COG5048   265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330
                  ....*....|.
gi 1126724274 465 THTGQKPYHCK 475
Cdd:COG5048   345 LHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-436 3.21e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 227 KPFHSLSSFQVHERIHTG-EKPFKCKQCGKAFSCSPTLRIHERT--HTGE--KPYEC--KQCGKAFSYLPSLRLHERIHT 299
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 300 GEKPFVCK--QCGKAFRSASTFQIHERT--HTGEKPYECKECGEAFSCIPSMRRHmikhtgegpykckvcgkpfhslsPF 375
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126724274 376 RIHERTHTGEKPYVCK--HCGKAFVSSTSIRIHERTHTGEKPYECKQCGKAFSYLNSFRTHEM 436
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-323 9.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274   3 ETMRNLASIGKKWKDQNIKDHYKHRGRNL---RSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKL-CESIVYGEV 78
Cdd:COG5048   160 NTPQSNSLHPPLPANSLSKDPSSNLSLLIssnVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLtTNSQLSPKS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274  79 SMGQSSLNRHIKDHSGHEPKEYQEYGekpDTRNQCWKPFSSHHSfrtheiihtgeklydckecgktffsLKRIRRhiith 158
Cdd:COG5048   240 LLSQSPSSLSSSDSSSSASESPRSSL---PTASSQSSSPNESDS-------------------------SSEKGF----- 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 159 sgYTPYKCKVCGKAFDYPSRFRTHERS--HTGE--KPYEC--QECGKAFTCITSVRRHMIKHTGDGPYKCK--VCGKPFH 230
Cdd:COG5048   287 --SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 231 SLS-----SFQVHERIHTGEKPFKC--KQCGKAFSCSPTLRIHERTHTGEKPYECK--QCGKAFSYLPSLRLHERIHTGE 301
Cdd:COG5048   365 PLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNH 444

                         330       340
                  ....*....|....*....|..
gi 1126724274 302 KPFVCKQCGKAFRSASTFQIHE 323
Cdd:COG5048   445 APLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-462 2.69e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 302 KPFVCKQCGKAFRSASTFQIHERT--HTGE--KPYECKE--CGEAFSCIPSMRRHMIKHTGEGPYKCK--VCGKPFHSLS 373
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126724274 374 PFRIHERTH-----TGEKPYVCKH--CGKAFVSSTSIRIHERTHTGEKPYECK--QCGKAFSYLNSFRTHEMIHTGEKPF 444
Cdd:COG5048   368 NNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1126724274 445 ECkRCGKAFRSSSSFRLH 462
Cdd:COG5048   448 LC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-287 7.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....*
gi 1126724274 263 LRIHERTHTGEKPYECKQCGKAFSY 287
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-259 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724274 234 SFQVHERIHTGEKPFKCKQCGKAFSC 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-315 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724274 290 SLRLHERIHTGEKPFVCKQCGKAFRS 315
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
178-203 1.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724274 178 RFRTHERSHTGEKPYECQECGKAFTC 203
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-427 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....
gi 1126724274 404 RIHERTHTGEKPYECKQCGKAFSY 427
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-343 5.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724274 319 FQIHERTHTGEKPYECKECGEAFSC 343
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-399 5.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.70e-03
                          10        20
                  ....*....|....*....|....*
gi 1126724274 375 FRIHERTHTGEKPYVCKHCGKAFVS 399
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-483 6.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|....*.
gi 1126724274 458 SFRLHERTHTGQKPYHCKECGKAYSC 483
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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