JAK1 Janus kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: JAK1provided by HGNC
Official Full Name: Janus kinase 1provided by HGNC
Primary source: HGNC:HGNC:6190
See related: Ensembl:ENSG00000162434 MIM:147795; AllianceGenome:HGNC:6190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JTK3; AIIDE; JAK1A; JAK1B
Summary: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression: Ubiquitous expression in lymph node (RPKM 51.3), fat (RPKM 49.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.3

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (64833229..65067746, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (64711228..64945755, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (65298912..65533429, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Janus kinase 1 is critical for pancreatic cancer initiation and progression.
Title: The Janus kinase 1 is critical for pancreatic cancer initiation and progression.
Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
Title: Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis.
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.
CD146[+]CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
Title: CD146(+)CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
Inhibiting JAK1, not NF-kappaB, reverses the effect of pro-inflammatory cytokines on engineered human ligament function.
Title: Inhibiting JAK1, not NF-κB, reverses the effect of pro-inflammatory cytokines on engineered human ligament function.
JAK1 promotes HDV replication and is a potential target for antiviral therapy.
Title: JAK1 promotes HDV replication and is a potential target for antiviral therapy.
WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
Title: WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.
Title: METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway.
RARgamma promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
Title: RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients.
Title: Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients.

Submit: New GeneRIF Correction See all GeneRIFs (225)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoinflammation, immune dysregulation, and eosinophilia MedGen: C5436572 OMIM: 618999 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of Janus kinase 1 (JAK1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells	PubMed
Knockdown of Janus kinase 1 (JAK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed
Knockdown of Janus kinase 1 (JAK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120	PubMed
Tat	tat	HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells	PubMed
	tat	Knockdown of JAK1 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay	PubMed
	tat	HIV-1 Tat-mediated activation of PIK3R1 hypothetically induces the modulation of JAK1	PubMed
matrix	gag	Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

JAK1-000F (e-PCR)
- UniSTS:38178

SHGC-74942 (e-PCR)
- UniSTS:10794

SHGC-74938 (e-PCR)
- UniSTS:33837

G22293 (e-PCR)
- UniSTS:63104

AL034288 (e-PCR)
- UniSTS:94108

SHGC-74955 (e-PCR)
- UniSTS:71385

RH123697 (e-PCR)
- UniSTS:135902

AL033825 (e-PCR)
- UniSTS:93690

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CCR5 chemokine receptor binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IC Inferred by Curator more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-10-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-11-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-15-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-2-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-2-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in interleukin-4-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-4-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in interleukin-7-mediated signaling pathway	IC Inferred by Curator more info	PubMed
involved_in interleukin-9-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to antibiotic	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in type II interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type II interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in type II interferon-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in type III interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	TAS Traceable Author Statement more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase JAK1

NP_001307852.1

EC 2.7.10.2

NP_001308781.1

EC 2.7.10.2

NP_001308782.1

EC 2.7.10.2

NP_001308783.1

EC 2.7.10.2

NP_001308784.1

EC 2.7.10.2

NP_001308785.1

EC 2.7.10.2

NP_001308786.1

EC 2.7.10.2

NP_002218.2

EC 2.7.10.2

XP_047275630.1

EC 2.7.10.2

XP_047275631.1

EC 2.7.10.2

XP_047275632.1

EC 2.7.10.2

XP_047275633.1

EC 2.7.10.2

XP_054192401.1

EC 2.7.10.2

XP_054192402.1

EC 2.7.10.2

XP_054192403.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023402.2 RefSeqGene

Range

106198..239518

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1398

mRNA and Protein(s)

NM_001320923.2 → NP_001307852.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Source sequence(s)

AC093427, AK314257, BC062431, BC132729

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000514243.1, ENST00000699262.1

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321852.2 → NP_001308781.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (3) initiates from an upstream promoter compared to variant 1.

Source sequence(s)

AC093427, AL357078

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000500745.2, ENST00000672751.2

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321853.2 → NP_001308782.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) initiates from an upstream promoter compared to variant 1.

Source sequence(s)

AC093427, AL357078, AL606517

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000499900.1, ENST00000672434.2

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321854.2 → NP_001308783.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5) initiates from an upstream promoter compared to variant 1.

Source sequence(s)

AC093427, AL357078

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000514291.1, ENST00000699312.1

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321855.2 → NP_001308784.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Source sequence(s)

AC093427, AL606517

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000499884.1, ENST00000672247.2

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321856.2 → NP_001308785.1 tyrosine-protein kinase JAK1 isoform 1

Status: REVIEWED

Source sequence(s)

AC093427, AL606517

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000500296.1, ENST00000672179.2

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain
NM_001321857.2 → NP_001308786.1 tyrosine-protein kinase JAK1 isoform 2

Status: REVIEWED

Source sequence(s)

AC093427, AL606517

Consensus CDS

CCDS90968.1

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39, A0A8V8TPQ9

Related

ENSP00000514241.1, ENST00000699260.1

Conserved Domains (7) summary

cd05079
Location:869 → 1152

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:874 → 1148

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:582 → 845

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:582 → 844

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 526

SH2; Src homology 2 (SH2) domain
NM_002227.4 → NP_002218.2 tyrosine-protein kinase JAK1 isoform 1

See identical proteins and their annotated locations for NP_002218.2

Status: REVIEWED

Source sequence(s)

AB209057, AC093427, AL606517, BC009079

Consensus CDS

CCDS41346.1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

UniProtKB/TrEMBL

A0A0A0N0M2, A0A5F9ZI39

Related

ENSP00000343204.4, ENST00000342505.5

Conserved Domains (7) summary

cd05079
Location:870 → 1153

PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1

smart00219
Location:875 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:37 → 286

B41; Band 4.1 homologues

cd05077
Location:583 → 846

PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1

cd13332
Location:282 → 426

FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

pfam07714
Location:583 → 845

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:426 → 527

SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

64833229..65067746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419676.1 → XP_047275632.1 tyrosine-protein kinase JAK1 isoform X2

UniProtKB/TrEMBL

A0A8V8TPQ9
XM_047419677.1 → XP_047275633.1 tyrosine-protein kinase JAK1 isoform X2

UniProtKB/TrEMBL

A0A8V8TPQ9
XM_047419675.1 → XP_047275631.1 tyrosine-protein kinase JAK1 isoform X1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26
XM_047419674.1 → XP_047275630.1 tyrosine-protein kinase JAK1 isoform X1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

64711228..64945755 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336427.1 → XP_054192402.1 tyrosine-protein kinase JAK1 isoform X2

UniProtKB/TrEMBL

A0A8V8TPQ9
XM_054336428.1 → XP_054192403.1 tyrosine-protein kinase JAK1 isoform X2

UniProtKB/TrEMBL

A0A8V8TPQ9
XM_054336426.1 → XP_054192401.1 tyrosine-protein kinase JAK1 isoform X1

UniProtKB/Swiss-Prot

P23458, Q59GQ2, Q9UD26