Obp2a odorant binding protein 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Obp2aprovided by RGD
Official Full Name: odorant binding protein 2Aprovided by RGD
Primary source: RGD:1588212
See related: AllianceGenome:RGD:1588212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lcn13; Obp2b
Summary: Predicted to enable small molecule binding activity. Predicted to act upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of gluconeogenesis; and regulation of lipid metabolic process. Predicted to be active in extracellular space. Orthologous to several human genes including OBP2A (odorant binding protein 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 2.7), Testes (RPKM 2.4) and 5 other tissues See more
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Genomic context

Location:: 3p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28904024..28907391)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8505963..8509269)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2908684..2913362)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification, characterization and expression analysis of rLcn13, an epididymal lipocalin in rats.
Title: Identification, characterization and expression analysis of rLcn13, an epididymal lipocalin in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables odorant binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: odorant binding protein 2A

Names: lipocalin 13; odorant binding protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128139.3 → NP_001121611.1 odorant binding protein 2A precursor

See identical proteins and their annotated locations for NP_001121611.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTA2, B3EY84, F7EU54

Conserved Domains (1) summary

pfam00061
Location:31 → 169

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28904024..28907391

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284542.1 → XP_063140612.1 odorant binding protein 2A isoform X1
XM_063284544.1 → XP_063140614.1 odorant binding protein 2A isoform X2

UniProtKB/TrEMBL

A6JTA2, B3EY84, F7EU54
XM_063284543.1 → XP_063140613.1 odorant binding protein 2A isoform X2

UniProtKB/TrEMBL

A6JTA2, B3EY84, F7EU54