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    GOLGA8A golgin A8 family member A [ Homo sapiens (human) ]

    Gene ID: 23015, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GOLGA8Aprovided by HGNC
    Official Full Name
    golgin A8 family member Aprovided by HGNC
    Primary source
    HGNC:HGNC:31972
    See related
    Ensembl:ENSG00000175265 MIM:616180; AllianceGenome:HGNC:31972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM88; FAP286; CFAP286; GOLGA8B
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 77.6), testis (RPKM 53.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GOLGA8A in Genome Data Viewer
    Location:
    15q14
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34379068..34437808, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32184804..32243499, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34671269..34730009, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6283 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:34659557-34660552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9181 Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene microRNA 1233-1 Neighboring gene amyloid beta precursor protein binding family A member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34710454-34710954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34710955-34711455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6286 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:34782687-34783188 Neighboring gene heterogeneous nuclear ribonucleoprotein L pseudogene 2 Neighboring gene fascin actin-bundling protein 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of Plasma Biomarkers of Human Intracerebral Hemorrhage Subtypes through Microarray Technology. Merino-Zamorano C, et al. J Stroke Cerebrovasc Dis, 2016 Mar. PMID 26738811
    2. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. Eystathioy T, et al. J Autoimmun, 2000 Mar. PMID 10677249
    3. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw A, et al. J Biol Chem, 2000 Feb 11. PMID 10660574
    4. Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1. Berthel E, et al. Cells, 2020 Apr 10. PMID 32290274, Free PMC Article
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 8A
    Names
    88 kDa Golgi matrix protein
    88-kDa golgi protein
    GM88 autoantigen
    Golgin subfamily A member 8B
    golgi autoantigen, golgin subfamily a, 8A
    golgin-67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368071.2 → NP_001355000.1  golgin subfamily A member 8A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes isoform 2.
      Source sequence(s)
      AC025678
      Consensus CDS
      CCDS91979.1
      UniProtKB/TrEMBL
      A0A8V8TPN8, B7ZKM1
      Related
      ENSP00000514395.1, ENST00000699472.1

    2. NM_001368072.2 → NP_001355001.1  golgin subfamily A member 8A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variant 3, encodes isoform 2.
      Source sequence(s)
      AC025678
      Consensus CDS
      CCDS91979.1
      UniProtKB/TrEMBL
      A0A8V8TPN8, B7ZKM1

    3. NM_001386893.1 → NP_001373822.1  golgin subfamily A member 8A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform 1.
      Source sequence(s)
      AC025678
      Consensus CDS
      CCDS10038.1
      UniProtKB/TrEMBL
      B7ZKM1
      Conserved Domains (3) summary
      TIGR02168
      Location:78 → 439
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:218 → 397
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:558 → 603
      GM130_C; GM130 C-terminal binding motif

    4. NM_001386895.1 → NP_001373824.1  golgin subfamily A member 8A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform 1.
      Source sequence(s)
      AC025678
      Consensus CDS
      CCDS10038.1
      UniProtKB/TrEMBL
      B7ZKM1
      Conserved Domains (3) summary
      TIGR02168
      Location:78 → 439
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:218 → 397
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:558 → 603
      GM130_C; GM130 C-terminal binding motif

    5. NM_181077.5 → NP_851422.1  golgin subfamily A member 8A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC025678
      Consensus CDS
      CCDS10038.1
      UniProtKB/TrEMBL
      B7ZKM1
      Related
      ENSP00000352111.4, ENST00000359187.5
      Conserved Domains (3) summary
      TIGR02168
      Location:78 → 439
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:218 → 397
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:558 → 603
      GM130_C; GM130 C-terminal binding motif

    RNA

    1. NR_027409.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate upstream promoter, contains additional 5' exons, and retains an intron, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC025678

    2. NR_164784.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025678

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      34379068..34437808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432259.1 → XP_047288215.1  golgin subfamily A member 8A isoform X1

    2. XM_047432261.1 → XP_047288217.1  golgin subfamily A member 8A isoform X1

    3. XM_047432258.1 → XP_047288214.1  golgin subfamily A member 8A isoform X1

      Related
      ENST00000473125.5

    4. XM_047432256.1 → XP_047288212.1  golgin subfamily A member 8A isoform X1

    5. XM_047432257.1 → XP_047288213.1  golgin subfamily A member 8A isoform X1

    6. XM_047432260.1 → XP_047288216.1  golgin subfamily A member 8A isoform X1

    7. XM_047432262.1 → XP_047288218.1  golgin subfamily A member 8A isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791798.1 Reference GRCh38.p14 PATCHES

      Range
      125171..183900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333174.1 → XP_054189149.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    2. XM_054333179.1 → XP_054189154.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    3. XM_054333176.1 → XP_054189151.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    4. XM_054333180.1 → XP_054189155.1  golgin subfamily A member 8A isoform X4

      UniProtKB/TrEMBL
      A0AAG2UVS0

    5. XM_054333173.1 → XP_054189148.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    6. XM_054333177.1 → XP_054189152.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    7. XM_054333178.1 → XP_054189153.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    8. XM_054333175.1 → XP_054189150.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    9. XM_054333181.1 → XP_054189156.1  golgin subfamily A member 8A isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      32184804..32243499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377546.1 → XP_054233521.1  golgin subfamily A member 8A isoform X4

      UniProtKB/TrEMBL
      A0AAG2UVS0

    2. XM_054377547.1 → XP_054233522.1  golgin subfamily A member 8A isoform X4

      UniProtKB/TrEMBL
      A0AAG2UVS0

    3. XM_054377544.1 → XP_054233519.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    4. XM_054377545.1 → XP_054233520.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    5. XM_054377542.1 → XP_054233517.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    6. XM_054377543.1 → XP_054233518.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    7. XM_054377541.1 → XP_054233516.1  golgin subfamily A member 8A isoform X3

      UniProtKB/TrEMBL
      A0AAG2UVG6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015003.4: Suppressed sequence

      Description
      NM_015003.4: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NM_181076.2: Suppressed sequence

      Description
      NM_181076.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7E2F4.3 GenPept UniProtKB/Swiss-Prot:A7E2F4
    A8MQT2.2 GenPept UniProtKB/Swiss-Prot:A8MQT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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