Zranb3 zinc finger, RAN-binding domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zranb3provided by MGI
Official Full Name: zinc finger, RAN-binding domain containing 3provided by MGI
Primary source: MGI:MGI:1918362
See related: Ensembl:ENSMUSG00000036086 AllianceGenome:MGI:1918362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AH2; C730006D09; 4933425L19Rik
Summary: Predicted to enable ATP-dependent DNA/DNA annealing activity; DNA endonuclease activity; and K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 1.7), limb E14.5 (RPKM 1.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E3; 1 55.8 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (127881916..128030799, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (127954179..128103053, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

42.MMHAP54FLF6.seq (e-PCR)
- UniSTS:124465

10.MMHAP95FRD7.seq (e-PCR)
- UniSTS:123058

RH136129 (e-PCR)
- UniSTS:210124

D1Mit393 (e-PCR), detects polymorphism
- UniSTS:128754

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA/DNA annealing activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent DNA/DNA annealing activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA rewinding	ISO Inferred from Sequence Orthology more info
involved_in DNA rewinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork reversal	IEA Inferred from Electronic Annotation more info
involved_in replication fork reversal	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA annealing helicase and endonuclease ZRANB3

Names: annealing helicase 2; zinc finger Ran-binding domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285945.1 → NP_001272874.1 DNA annealing helicase and endonuclease ZRANB3 isoform 2

Status: VALIDATED

Source sequence(s)

AC131995, AK016921, BC066035

UniProtKB/Swiss-Prot

Q6NZP1

UniProtKB/TrEMBL

Q9D3Z7

Conserved Domains (6) summary

smart00547
Location:625 → 647

ZnF_RBZ; Zinc finger domain

smart00487
Location:33 → 216

DEXDc; DEAD-like helicases superfamily

cd00046
Location:59 → 194

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00085
Location:978 → 1043

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:625 → 644

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00271
Location:334 → 439

Helicase_C; Helicase conserved C-terminal domain
NM_001357573.1 → NP_001344502.1 DNA annealing helicase and endonuclease ZRANB3 isoform 1

Status: VALIDATED

Source sequence(s)

AC129545, AC131995

Consensus CDS

CCDS35697.1

UniProtKB/Swiss-Prot

Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6

Related

ENSMUSP00000108157.3, ENSMUST00000112538.4

Conserved Domains (4) summary

smart00547
Location:621 → 643

ZnF_RBZ; Zinc finger domain

COG0553
Location:7 → 477

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:974 → 1039

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:621 → 640

zf-RanBP2; RanBP2-type Zn finger [structural motif]
NM_027678.3 → NP_081954.1 DNA annealing helicase and endonuclease ZRANB3 isoform 1

See identical proteins and their annotated locations for NP_081954.1

Status: VALIDATED

Source sequence(s)

AC129545, AC131995, AK084943, BC066035

Consensus CDS

CCDS35697.1

UniProtKB/Swiss-Prot

Q148X9, Q6NZP1, Q8BJJ3, Q8BWT6

Related

ENSMUSP00000083806.6, ENSMUST00000086614.12

Conserved Domains (4) summary

smart00547
Location:621 → 643

ZnF_RBZ; Zinc finger domain

COG0553
Location:7 → 477

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:974 → 1039

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:621 → 640

zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

127881916..128030799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529408.2 → XP_006529471.1 DNA annealing helicase and endonuclease ZRANB3 isoform X1

Conserved Domains (5) summary

smart00547
Location:625 → 647

ZnF_RBZ; Zinc finger domain

COG0553
Location:11 → 481

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:1025 → 1090

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:625 → 644

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:41 → 260

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_036163815.1 → XP_036019708.1 DNA annealing helicase and endonuclease ZRANB3 isoform X3

Conserved Domains (5) summary

smart00547
Location:561 → 583

ZnF_RBZ; Zinc finger domain

COG0553
Location:1 → 417

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:961 → 1026

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:561 → 580

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:1 → 196

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_006529411.5 → XP_006529474.1 DNA annealing helicase and endonuclease ZRANB3 isoform X2

See identical proteins and their annotated locations for XP_006529474.1

Conserved Domains (5) summary

smart00547
Location:621 → 643

ZnF_RBZ; Zinc finger domain

COG0553
Location:7 → 477

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:1021 → 1086

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:621 → 640

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:37 → 256

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_006529410.2 → XP_006529473.1 DNA annealing helicase and endonuclease ZRANB3 isoform X2

See identical proteins and their annotated locations for XP_006529473.1

Conserved Domains (5) summary

smart00547
Location:621 → 643

ZnF_RBZ; Zinc finger domain

COG0553
Location:7 → 477

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:1021 → 1086

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:621 → 640

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:37 → 256

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_036163817.1 → XP_036019710.1 DNA annealing helicase and endonuclease ZRANB3 isoform X3

Conserved Domains (5) summary

smart00547
Location:561 → 583

ZnF_RBZ; Zinc finger domain

COG0553
Location:1 → 417

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:961 → 1026

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:561 → 580

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:1 → 196

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_030253114.1 → XP_030108974.1 DNA annealing helicase and endonuclease ZRANB3 isoform X3

Conserved Domains (5) summary

smart00547
Location:561 → 583

ZnF_RBZ; Zinc finger domain

COG0553
Location:1 → 417

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:961 → 1026

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:561 → 580

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:1 → 196

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_006529409.1 → XP_006529472.1 DNA annealing helicase and endonuclease ZRANB3 isoform X2

See identical proteins and their annotated locations for XP_006529472.1

Conserved Domains (5) summary

smart00547
Location:621 → 643

ZnF_RBZ; Zinc finger domain

COG0553
Location:7 → 477

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:1021 → 1086

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:621 → 640

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:37 → 256

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_030253115.1 → XP_030108975.1 DNA annealing helicase and endonuclease ZRANB3 isoform X4

Conserved Domains (5) summary

smart00547
Location:561 → 583

ZnF_RBZ; Zinc finger domain

COG0553
Location:1 → 417

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd00085
Location:914 → 979

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:561 → 580

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18010
Location:1 → 196

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
XM_036163819.1 → XP_036019712.1 DNA annealing helicase and endonuclease ZRANB3 isoform X5

Conserved Domains (4) summary

smart00547
Location:290 → 312

ZnF_RBZ; Zinc finger domain

cd00085
Location:690 → 755

HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

sd00029
Location:290 → 309

zf-RanBP2; RanBP2-type Zn finger [structural motif]

cd18793
Location:9 → 115

SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
XM_006529416.3 → XP_006529479.1 DNA annealing helicase and endonuclease ZRANB3 isoform X6

See identical proteins and their annotated locations for XP_006529479.1

UniProtKB/TrEMBL

Q8BUI4, Q9D3Z7

Conserved Domains (2) summary

COG0553
Location:11 → 481

HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

cd18010
Location:41 → 260

DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1