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    MDP1 magnesium dependent phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 145553, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MDP1provided by HGNC
    Official Full Name
    magnesium dependent phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:28781
    See related
    Ensembl:ENSG00000213920 AllianceGenome:HGNC:28781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDP-1; FN6PASE
    Summary
    Predicted to enable acid phosphatase activity. Predicted to be involved in fructosamine metabolic process and peptidyl-tyrosine dephosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 7.9), kidney (RPKM 7.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See MDP1 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24213943..24216066, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18412319..18414442, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24683149..24685272, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer. Zhu J, et al. Curr Cancer Drug Targets, 2019. PMID 31218958
    2. Expression and prognostic roles of magnesium-dependent phosphatase-1 in gastric cancer. Chen Y, et al. Eur Rev Med Pharmacol Sci, 2017 Jun. PMID 28678323
    3. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. Fortpied J, et al. J Biol Chem, 2006 Jul 7. PMID 16670083
    4. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Selengut JD, et al. Biochemistry, 2000 Jul 18. PMID 10889041
    5. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CHMP4A

    Readthrough NEDD8-MDP1

    Readthrough gene: NEDD8-MDP1, Included gene: NEDD8

    Homology

    Clone Names

    • MGC5987

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    magnesium-dependent phosphatase 1
    Names
    fructosamine-6-phosphatase
    NP_001186750.1
    NP_001186751.1
    NP_001399117.1
    NP_612485.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199821.2 → NP_001186750.1  magnesium-dependent phosphatase 1 isoform 2

      See identical proteins and their annotated locations for NP_001186750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC046912, DA287183
      Consensus CDS
      CCDS55908.1
      UniProtKB/Swiss-Prot
      Q86V88
      Related
      ENSP00000380045.2, ENST00000396833.2
      Conserved Domains (1) summary
      cl21460
      Location:3 → 86
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001199822.2 → NP_001186751.1  magnesium-dependent phosphatase 1 isoform 3

      See identical proteins and their annotated locations for NP_001186751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA918790, CB046258, DA287183
      Conserved Domains (1) summary
      pfam12689
      Location:3 → 135
      Acid_PPase; Acid Phosphatase

    3. NM_001412188.1 → NP_001399117.1  magnesium-dependent phosphatase 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents an alternate allele of variant 1 on T2TCHM13v2.0 assembly (rs3215610). It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      CP068264

    4. NM_138476.4 → NP_612485.2  magnesium-dependent phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_612485.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA918790, BC051382, DA287183
      Consensus CDS
      CCDS9620.1
      UniProtKB/Swiss-Prot
      Q86V88, Q86Y84, Q8NAD9
      Related
      ENSP00000288087.7, ENST00000288087.12
      Conserved Domains (1) summary
      pfam12689
      Location:3 → 160
      Acid_PPase; Acid Phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24213943..24216066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      514921..517044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18412319..18414442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86V88.1 GenPept UniProtKB/Swiss-Prot:Q86V88

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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