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NEDD8-MDP1 NEDD8-MDP1 readthrough [ Homo sapiens (human) ]

Gene ID: 100528064, updated on 3-Apr-2024

Summary

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Official Symbol
NEDD8-MDP1provided by HGNC
Official Full Name
NEDD8-MDP1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:39551
See related
Ensembl:ENSG00000255526 AllianceGenome:HGNC:39551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in kidney (RPKM 46.4), fat (RPKM 46.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
14q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24213943..24232367, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18412319..18430739, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24683149..24701573, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene magnesium dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24710068-24710597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8200 Neighboring gene TERF1 interacting nuclear factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
  3. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Shen R, et al. Transl Neurodegener, 2020 Jun 18. PMID 32552912, Free PMC Article
  4. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article
  5. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough NEDD8-MDP1

Included genes: NEDD8, MDP1

Homology

General protein information

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Preferred Names
NEDD8-MDP1 protein
Names
NEDD8-MDP1 read-through transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051059.1 RefSeqGene

    Range
    5001..23449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199823.3 → NP_001186752.1  NEDD8-MDP1 protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
    Source sequence(s)
    AL096870, DN993851
    UniProtKB/TrEMBL
    E9PL57
    Related
    ENSP00000431482.1, ENST00000534348.5
    Conserved Domains (3) summary
    smart00213
    Location:1 → 50
    UBQ; Ubiquitin homologues
    pfam12689
    Location:51 → 177
    Acid_PPase; Acid Phosphatase
    cl00155
    Location:1 → 51
    UBQ; Ubiquitin-like proteins

  2. NM_001412116.1 → NP_001399045.1  NEDD8-MDP1 protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses the same exon combination as variant 1 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    CP068264

RNA

  1. NR_137630.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL096870, CB070148

  2. NR_137631.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL096870, FY211956

  3. NR_137632.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL096870, FY212610
    Related
    ENST00000604306.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24213943..24232367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    514921..533345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18412319..18430739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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