nedd1 NEDD1 gamma-tubulin ring complex targeting factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nedd1provided by ZNC
Official Full Name: NEDD1 gamma-tubulin ring complex targeting factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2906
See related: Ensembl:ENSDARG00000013472 AllianceGenome:ZFIN:ZDB-GENE-040426-2906
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb78g03; zgc:63491; wu:fb78g03
Summary: Predicted to enable gamma-tubulin binding activity. Acts upstream of or within protein localization to centrosome. Located in centrosome and cytoplasm. Is expressed in central nervous system; neural tube; optic cup; and solid lens vesicle. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (19541021..19556974)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (19443070..19459023)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zNEDD1 is essential for survival, as a high level of knockdown was embryonic lethal. Partial knockdown of zNEDD1 caused abnormalities including an increase in mitotic and apoptotic cells.
Title: An essential function for the centrosomal protein NEDD1 in zebrafish development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fb78g03.x1 (e-PCR)
- UniSTS:191445

fb78g03.x1 (e-PCR)
- UniSTS:191446

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: protein NEDD1

Names: neural precursor cell expressed, developmentally down-regulated 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213506.1 → NP_998671.1 protein NEDD1

See identical proteins and their annotated locations for NP_998671.1

Status: PROVISIONAL

Source sequence(s)

BC058053

UniProtKB/TrEMBL

Q6PEI2

Conserved Domains (3) summary

COG2319
Location:14 → 301

WD40; WD40 repeat [General function prediction only]

cd00200
Location:34 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:38 → 77

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

19541021..19556974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163004.5 → XP_005163061.1 protein NEDD1 isoform X1

See identical proteins and their annotated locations for XP_005163061.1

UniProtKB/TrEMBL

A0A8M2BA03, F1QAL1

Related

ENSDARP00000016280.8, ENSDART00000027740.8

Conserved Domains (3) summary

COG2319
Location:14 → 301

WD40; WD40 repeat [General function prediction only]

cd00200
Location:34 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:38 → 77

7WD40; WD40 repeat [structural motif]