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Conserved domains on  [gi|528521434|ref|XP_005163061|]
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protein NEDD1 isoform X1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-299 3.12e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 3.12e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  34 THPVAQVCWSSSNQYVVSASSIGDKLVVSSlksSPVPVMELGEGKKQ--TRVSLNSTSQFLVSGGLDNTVNIWDLKTKRL 111
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDL---ETGELLRTLKGHTGpvRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 112 HRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPF-GHgpNVPIHDLRYSLVKRsLLGTVSDSGSVALW 190
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGT-FVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 191 DANTQKELHLFEGaHKAPCSGLAFSPANDLLFVTvGLDKKIVCYDTSSKI---VFRNKqvESPLTAIDFTPDGAGLVVGS 267
Cdd:cd00200  163 DLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKclgTLRGH--ENGVNSVAFSPDGYLLASGS 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 528521434 268 TQGRIYLYDLRNLSaPVKINTAHKTSVTCIRF 299
Cdd:cd00200  239 EDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-299 3.12e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 3.12e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  34 THPVAQVCWSSSNQYVVSASSIGDKLVVSSlksSPVPVMELGEGKKQ--TRVSLNSTSQFLVSGGLDNTVNIWDLKTKRL 111
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDL---ETGELLRTLKGHTGpvRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 112 HRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPF-GHgpNVPIHDLRYSLVKRsLLGTVSDSGSVALW 190
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGT-FVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 191 DANTQKELHLFEGaHKAPCSGLAFSPANDLLFVTvGLDKKIVCYDTSSKI---VFRNKqvESPLTAIDFTPDGAGLVVGS 267
Cdd:cd00200  163 DLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKclgTLRGH--ENGVNSVAFSPDGYLLASGS 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 528521434 268 TQGRIYLYDLRNLSaPVKINTAHKTSVTCIRF 299
Cdd:cd00200  239 EDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
3-279 3.44e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.51  E-value: 3.44e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434   3 DVTRLVSSGD--CLKIWDSSSMTVVEQFNPHsaTHPVAQVCWSSSNQYVVSASSigDKLV----------VSSLKSSPVP 70
Cdd:COG2319  131 DGKTLASGSAdgTVRLWDLATGKLLRTLTGH--SGAVTSVAFSPDGKLLASGSD--DGTVrlwdlatgklLRTLTGHTGA 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  71 VmelgegkkqTRVSLNSTSQFLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITT 150
Cdd:COG2319  207 V---------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 151 NLSSKPFGHGPNvPIHDLRYSLVKRSLLgTVSDSGSVALWDANTQKELHLFEGaHKAPCSGLAFSPANDLLfVTVGLDKK 230
Cdd:COG2319  278 GELLRTLTGHSG-GVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGT 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528521434 231 IVCYDTSS-KIVFRNKQVESPLTAIDFTPDGAGLVVGSTQGRIYLYDLRN 279
Cdd:COG2319  354 VRLWDLATgELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 1.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528521434   108 TKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-153 4.32e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  70 PVMELGEGKKQTRVSLNS--TSQfLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGD-SYIASGSTSGDIILH 146
Cdd:PLN00181 525 PVVELASRSKLSGICWNSyiKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLW 603


                 ....*..
gi 528521434 147 SITTNLS 153
Cdd:PLN00181 604 SINQGVS 610
WD40 pfam00400
WD domain, G-beta repeat;
109-147 2.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528521434  109 KRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHS 147
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-299 3.12e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 3.12e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  34 THPVAQVCWSSSNQYVVSASSIGDKLVVSSlksSPVPVMELGEGKKQ--TRVSLNSTSQFLVSGGLDNTVNIWDLKTKRL 111
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDL---ETGELLRTLKGHTGpvRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 112 HRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPF-GHgpNVPIHDLRYSLVKRsLLGTVSDSGSVALW 190
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGT-FVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 191 DANTQKELHLFEGaHKAPCSGLAFSPANDLLFVTvGLDKKIVCYDTSSKI---VFRNKqvESPLTAIDFTPDGAGLVVGS 267
Cdd:cd00200  163 DLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKclgTLRGH--ENGVNSVAFSPDGYLLASGS 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 528521434 268 TQGRIYLYDLRNLSaPVKINTAHKTSVTCIRF 299
Cdd:cd00200  239 EDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAW 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-276 1.84e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 1.84e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434   7 LVSSGD-CLKIWDSSSMTVVEQFNPHsaTHPVAQVCWSSSNQYVVSASSigDKLVVSSLKSSPVPVMELGEGKKQTR-VS 84
Cdd:cd00200   25 ATGSGDgTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTLTGHTSYVSsVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  85 LNSTSQFLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPFgHGPNVP 164
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 165 IHDLRYSLVKRSLLGTVSDsGSVALWDANTQKELHLFEGaHKAPCSGLAFSPaNDLLFVTVGLDKKIVCYDTSS-KIVFR 243
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRG-HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTgECVQT 256

                        250       260       270
                 ....*....|....*....|....*....|...
gi 528521434 244 NKQVESPLTAIDFTPDGAGLVVGSTQGRIYLYD 276
Cdd:cd00200  257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-279 3.44e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.51  E-value: 3.44e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434   3 DVTRLVSSGD--CLKIWDSSSMTVVEQFNPHsaTHPVAQVCWSSSNQYVVSASSigDKLV----------VSSLKSSPVP 70
Cdd:COG2319  131 DGKTLASGSAdgTVRLWDLATGKLLRTLTGH--SGAVTSVAFSPDGKLLASGSD--DGTVrlwdlatgklLRTLTGHTGA 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  71 VmelgegkkqTRVSLNSTSQFLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITT 150
Cdd:COG2319  207 V---------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 151 NLSSKPFGHGPNvPIHDLRYSLVKRSLLgTVSDSGSVALWDANTQKELHLFEGaHKAPCSGLAFSPANDLLfVTVGLDKK 230
Cdd:COG2319  278 GELLRTLTGHSG-GVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGT 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 528521434 231 IVCYDTSS-KIVFRNKQVESPLTAIDFTPDGAGLVVGSTQGRIYLYDLRN 279
Cdd:COG2319  354 VRLWDLATgELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
3-299 6.48e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 6.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434   3 DVTRLVSSGDCLKIWDSSSMTVVEQFNPHsaTHPVAQVCWSSSNQYVVSASSIGdKLVVSSLKSSPVPVMELGEGKKQTR 82
Cdd:COG2319   49 ARLAAGAGDLTLLLLDAAAGALLATLLGH--TAAVLSVAFSPDGRLLASASADG-TVRLWDLATGLLLRTLTGHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  83 VSLNSTSQFLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPFGhGPN 162
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 163 VPIHDLRYSLvKRSLLGTVSDSGSVALWDANTQKELHLFEGaHKAPCSGLAFSPANDLLfVTVGLDKKIVCYDTSS-KIV 241
Cdd:COG2319  205 GAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLL-ASGSADGTVRLWDLATgELL 281

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528521434 242 FRNKQVESPLTAIDFTPDGAGLVVGSTQGRIYLYDLRNlSAPVKINTAHKTSVTCIRF 299
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
31-299 1.46e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 1.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  31 HSATHPVAQVCWSSSNQYVVSASSIGDKLVVSSLKSSPVPVMELGEGKKQTRVSLNSTSQFLVSGGLDNTVNIWDLKTKR 110
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 111 LHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKPFgHGPNVPIHDLRYSLVKRSLLgTVSDSGSVALW 190
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLA-SGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 191 DANTQKELHLFEGaHKAPCSGLAFSPANDLLfVTVGLDKKIVCYDTSS-KIVFRNKQVESPLTAIDFTPDGAGLVVGSTQ 269
Cdd:COG2319  190 DLATGKLLRTLTG-HTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        250       260       270
                 ....*....|....*....|....*....|
gi 528521434 270 GRIYLYDLRNlSAPVKINTAHKTSVTCIRF 299
Cdd:COG2319  268 GTVRLWDLAT-GELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-299 5.58e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 5.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 111 LHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHSITTNLSSKpFGHGPNVPIHDLRYSLVKRSLLgTVSDSGSVALW 190
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 191 DANTQKELHLFEGaHKAPCSGLAFSPANDLLfVTVGLDKKIVCYDTSS---KIVFRNKqvESPLTAIDFTPDGAGLVVGS 267
Cdd:cd00200   79 DLETGECVRTLTG-HTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETgkcLTTLRGH--TDWVNSVAFSPDGTFVASSS 154

                        170       180       190
                 ....*....|....*....|....*....|..
gi 528521434 268 TQGRIYLYDLRNLSaPVKINTAHKTSVTCIRF 299
Cdd:cd00200  155 QDGTIKLWDLRTGK-CVATLTGHTGEVNSVAF 185
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-145 1.73e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434   6 RLVSSGD---CLKIWDSSSMTVVEQFNPHsaTHPVAQVCWSSSNQYVVSASS--------IGDKLVVSSLKSSPVPVMEl 74
Cdd:cd00200  148 TFVASSSqdgTIKLWDLRTGKCVATLTGH--TGEVNSVAFSPDGEKLLSSSSdgtiklwdLSTGKCLGTLRGHENGVNS- 224

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528521434  75 gegkkqtrVSLNSTSQFLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIIL 145
Cdd:cd00200  225 --------VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
125-279 4.59e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 4.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 125 VSFNGGDSYIASGSTSGDIILHSITTNLSSKPFGHGPNVPIHDLRYSLVKRSLLGTVSDSGSVALWDANTQKELHLFE-G 203
Cdd:COG3391   30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPvG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 204 AHkapCSGLAFSPANDLLFVTVGLDKKIVCYDTSS-KIVFRNKQVESPlTAIDFTPDGAGLVVGSTQGR-----IYLYDL 277
Cdd:COG3391  110 GG---PRGLAVDPDGGRLYVADSGNGRVSVIDTATgKVVATIPVGAGP-HGIAVDPDGKRLYVANSGSNtvsviVSVIDT 185


                 ..
gi 528521434 278 RN 279
Cdd:COG3391  186 AT 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 1.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528521434   108 TKRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 70-153 4.32e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  70 PVMELGEGKKQTRVSLNS--TSQfLVSGGLDNTVNIWDLKTKRLHRTLKDHKEEVTCVSFNGGD-SYIASGSTSGDIILH 146
Cdd:PLN00181 525 PVVELASRSKLSGICWNSyiKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLW 603


                 ....*..
gi 528521434 147 SITTNLS 153
Cdd:PLN00181 604 SINQGVS 610
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
93-238 4.60e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434  93 VSGGLDNTVNIWDLKTKRLHRTLK--DHKEEVtCVSFNGGDSYIASgSTSGDIILHSITTN--LSSKPFGHGPnvpiHDL 168
Cdd:COG3391   84 VANSGSGRVSVIDLATGKVVATIPvgGGPRGL-AVDPDGGRLYVAD-SGNGRVSVIDTATGkvVATIPVGAGP----HGI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 169 RYSLVKRSLLgtVSDSGS------VALWDANTQKELHLFEGAHKApcSGLAFSPANDLLFVT-------VGLDKKIVCYD 235
Cdd:COG3391  158 AVDPDGKRLY--VANSGSntvsviVSVIDTATGKVVATIPVGGGP--VGVAVSPDGRRLYVAnrgsntsNGGSNTVSVID 233


                 ...
gi 528521434 236 TSS 238
Cdd:COG3391  234 LAT 236
WD40 COG2319
WD40 repeat [General function prediction only];
175-299 1.07e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528521434 175 RSLLGTVSDSGSVALWDANTQKELHLFEGaHKAPCSGLAFSPANDLLFVTVGLDKKIVCYDTSSKIVFRNKQVESPLTAI 254
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLG-LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 528521434 255 DFTPDGAGLVVGSTQGRIYLYDLRNlSAPVKINTAHKTSVTCIRF 299
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAF 128
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 234-279 1.88e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.06  E-value: 1.88e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 528521434 234 YDTSSK------IVFRnkqvESPLTAIDFTPDGAGLVVGSTQGRIYLYDLRN 279
Cdd:cd22857  207 YDTRAQrrpvvsVDFG----ETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
WD40 pfam00400
WD domain, G-beta repeat;
109-147 2.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 528521434  109 KRLHRTLKDHKEEVTCVSFNGGDSYIASGSTSGDIILHS 147
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 194-235 9.32e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 9.32e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 528521434   194 TQKELHLFEGaHKAPCSGLAFSPaNDLLFVTVGLDKKIVCYD 235
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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