CYLD CYLD lysine 63 deubiquitinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYLDprovided by HGNC
Official Full Name: CYLD lysine 63 deubiquitinaseprovided by HGNC
Primary source: HGNC:HGNC:2584
See related: Ensembl:ENSG00000083799 MIM:605018; AllianceGenome:HGNC:2584
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2; FTDALS8
Summary: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 13.0), lymph node (RPKM 10.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (50742086..50801935)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (56539727..56599616)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (50775997..50835846)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.
Title: Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.
Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis.
Title: Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis.
Megalosplenia as an initial manifestation of multiple myeloma with a novel CYLD gene mutation: A case report and literature review.
Title: Megalosplenia as an initial manifestation of multiple myeloma with a novel CYLD gene mutation: A case report and literature review.
TNF and IFNgamma-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Title: TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma.
Title: CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma.
CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression.
Title: CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression.
YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling.
Title: YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling.
An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses.
Title: An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses.
Expanding CYLD protein in NF-kappabeta/TNF-alpha signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients.
Title: Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients.
CYLD stimulates macrophage phagocytosis of leukemic cells through STAT1 signalling in acute myeloid leukemia.
Title: CYLD stimulates macrophage phagocytosis of leukemic cells through STAT1 signalling in acute myeloid leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (209)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Brooke-Spiegler syndrome MedGen: C1857941 OMIM: 605041 GeneReviews: CYLD Cutaneous Syndrome	not available
Familial cylindromatosis MedGen: C1851526 OMIM: 132700 GeneReviews: CYLD Cutaneous Syndrome	not available
Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 MedGen: C5436881 OMIM: 619132 GeneReviews: Not available	not available
Trichoepithelioma, multiple familial, 1 MedGen: CN296585 OMIM: 601606 GeneReviews: CYLD Cutaneous Syndrome	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2021-02-10) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2021-02-10) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of CYLD by siRNA enhances HIV-1 infection in a single-cycle assay in HEK 293T cells, and the CYLD catalytic mutant C698A fails to reduce HIV-1 infection in 293T cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 transcription increases upon CYLD knockdown in CD4+ T lymphocytes, leading to upregulation of HIV-1 Gag/p24 levels in cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC32374 (e-PCR)
- UniSTS:28941

RH64884 (e-PCR)
- UniSTS:83726

D16S514 (e-PCR)
- UniSTS:20238

D16S308 (e-PCR)
- UniSTS:26139

RH94254 (e-PCR)
- UniSTS:88351

D16S503 (e-PCR)
- UniSTS:16470

CYLD__4662 (e-PCR)
- UniSTS:471409

D13S1553 (e-PCR)
- UniSTS:473482

G67954 (e-PCR)
- UniSTS:225683

SHGC-78760 (e-PCR)
- UniSTS:95637

G67953 (e-PCR)
- UniSTS:225686

D16S2680 (e-PCR)
- UniSTS:153250

RH92056 (e-PCR)
- UniSTS:91338

RH48312 (e-PCR)
- UniSTS:65489

SHGC-60837 (e-PCR)
- UniSTS:67819

Clone Names

HSPC057, FLJ20180, FLJ31664, FLJ78684, KIAA0849

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables K63-linked deubiquitinase activity	EXP Inferred from Experiment more info	PubMed
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables K63-linked deubiquitinase activity	TAS Traceable Author Statement more info
enables Met1-linked polyubiquitin deubiquitinase activity	EXP Inferred from Experiment more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	TAS Traceable Author Statement more info
enables proline-rich region binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-18-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of type I interferon production	TAS Traceable Author Statement more info
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS Traceable Author Statement more info
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	TAS Traceable Author Statement more info
involved_in protein linear deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in ripoptosome assembly involved in necroptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary tip	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
colocalizes_with midbody	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase CYLD

Names: cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD

NP_001035814.1

EC 3.4.19.12

NP_001035877.1

EC 3.4.19.12

NP_001365672.1

EC 3.4.19.12

NP_001365673.1

EC 3.4.19.12

NP_001365674.1

EC 3.4.19.12

NP_001365675.1

EC 3.4.19.12

NP_001365676.1

EC 3.4.19.12

NP_001365677.1

EC 3.4.19.12

NP_001365678.1

EC 3.4.19.12

NP_001365679.1

EC 3.4.19.12

NP_001365680.1

EC 3.4.19.12

NP_001365681.1

EC 3.4.19.12

NP_001365682.1

EC 3.4.19.12

NP_001365683.1

EC 3.4.19.12

NP_001365684.1

EC 3.4.19.12

NP_056062.1

EC 3.4.19.12

XP_047289612.1

EC 3.4.19.12

XP_047289614.1

EC 3.4.19.12

XP_047289615.1

EC 3.4.19.12

XP_047289616.1

EC 3.4.19.12

XP_047289617.1

EC 3.4.19.12

XP_047289618.1

EC 3.4.19.12

XP_047289619.1

EC 3.4.19.12

XP_047289620.1

EC 3.4.19.12

XP_054235669.1

EC 3.4.19.12

XP_054235670.1

EC 3.4.19.12

XP_054235671.1

EC 3.4.19.12

XP_054235672.1

EC 3.4.19.12

XP_054235673.1

EC 3.4.19.12

XP_054235674.1

EC 3.4.19.12

XP_054235675.1

EC 3.4.19.12

XP_054235676.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012061.1 RefSeqGene

Range

5001..64886

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_491

mRNA and Protein(s)

NM_001042355.2 → NP_001035814.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

See identical proteins and their annotated locations for NP_001035814.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks one exon in the 5' UTR and a second in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AJ250014, AK056226, AL050166, BI458962, BX642061, DA157717, DA785459, DA940312

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000457576.1, ENST00000569418.5

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001042412.3 → NP_001035877.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

See identical proteins and their annotated locations for NP_001035877.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' terminal exon, and lacks one exon in the 5' UTR and another in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000381574.2, ENST00000398568.6

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378743.1 → NP_001365672.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS45482.1

UniProtKB/Swiss-Prot

O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000392025.3, ENST00000427738.8

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378744.1 → NP_001365673.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000454515.1, ENST00000564326.5

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378745.1 → NP_001365674.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378746.1 → NP_001365675.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378747.1 → NP_001365676.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378748.1 → NP_001365677.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378749.1 → NP_001365678.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378750.1 → NP_001365679.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

Status: REVIEWED

Source sequence(s)

AC007728

Consensus CDS

CCDS42164.1

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:469 → 537

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:590 → 945

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 468

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378751.1 → NP_001365680.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

Status: REVIEWED

Source sequence(s)

AC007728

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:459 → 527

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:580 → 935

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 458

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378752.1 → NP_001365681.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

Status: REVIEWED

Source sequence(s)

AC007728

UniProtKB/TrEMBL

A8KAB0

Conserved Domains (3) summary

smart01052
Location:459 → 527

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:580 → 935

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 458

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378753.1 → NP_001365682.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 3

Status: REVIEWED

Source sequence(s)

AC007728

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000456488.2, ENST00000568704.2

Conserved Domains (3) summary

smart01052
Location:459 → 527

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:580 → 935

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 458

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378754.1 → NP_001365683.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

Status: REVIEWED

Source sequence(s)

AC007728

UniProtKB/TrEMBL

B3KND1

Conserved Domains (3) summary

smart01052
Location:247 → 315

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:368 → 723

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:82 → 246

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001378755.1 → NP_001365684.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 4

Status: REVIEWED

Source sequence(s)

AC007728

UniProtKB/TrEMBL

B3KND1

Conserved Domains (3) summary

smart01052
Location:247 → 315

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:368 → 723

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:82 → 246

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_015247.3 → NP_056062.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

See identical proteins and their annotated locations for NP_056062.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC007728

Consensus CDS

CCDS45482.1

UniProtKB/Swiss-Prot

O94934, Q7L3N6, Q96EH0, Q9NQC7, Q9NZX9

UniProtKB/TrEMBL

A8KAB0

Related

ENSP00000308928.9, ENST00000311559.13

Conserved Domains (3) summary

smart01052
Location:472 → 540

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:593 → 948

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 471

CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RNA

NR_166071.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007728

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

50742086..50801935

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433656.1 → XP_047289612.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_047433661.1 → XP_047289617.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2
XM_047433663.1 → XP_047289619.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3
XM_047433664.1 → XP_047289620.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4
XM_047433658.1 → XP_047289614.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_047433662.1 → XP_047289618.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2
XM_047433659.1 → XP_047289615.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_047433660.1 → XP_047289616.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

RNA

XR_007064858.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

56539727..56599616

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054379694.1 → XP_054235669.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_054379698.1 → XP_054235673.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2
XM_054379700.1 → XP_054235675.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3
XM_054379701.1 → XP_054235676.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4
XM_054379695.1 → XP_054235670.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_054379699.1 → XP_054235674.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2
XM_054379696.1 → XP_054235671.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1
XM_054379697.1 → XP_054235672.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2