CHD7 chromodomain helicase DNA binding protein 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHD7provided by HGNC
Official Full Name: chromodomain helicase DNA binding protein 7provided by HGNC
Primary source: HGNC:HGNC:20626
See related: Ensembl:ENSG00000171316 MIM:608892; AllianceGenome:HGNC:20626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRG; HH5; IS3; KAL5
Summary: This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression: Ubiquitous expression in bone marrow (RPKM 6.4), brain (RPKM 4.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q12.2

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (60678740..60868028)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (61102480..61291800)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (61591299..61780587)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHD7 Disorder-Not CHARGE Syndrome-Presenting as Isolated Cochleovestibular Dysfunction.
Title: CHD7 Disorder-Not CHARGE Syndrome-Presenting as Isolated Cochleovestibular Dysfunction.
Maternal CHD7 gonosomal mosaicism in a fetus with CHARGE syndrome.
Title: Maternal CHD7 gonosomal mosaicism in a fetus with CHARGE syndrome.
CHD7 and SOX2 act in a common gene regulatory network during mammalian semicircular canal and cochlear development.
Title: CHD7 and SOX2 act in a common gene regulatory network during mammalian semicircular canal and cochlear development.
A novel CHD7 variant in a chinese family with CHARGE syndrome.
Title: A novel CHD7 variant in a chinese family with CHARGE syndrome.
Expanding the reproductive organ phenotype of CHD7-spectrum disorder.
Title: Expanding the reproductive organ phenotype of CHD7-spectrum disorder.
The spectrum of cochlear malformations in CHARGE syndrome and insights into the role of the CHD7 gene during embryogenesis of the inner ear.
Title: The spectrum of cochlear malformations in CHARGE syndrome and insights into the role of the CHD7 gene during embryogenesis of the inner ear.
Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells.
Title: Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells.
CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids.
Title: CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids.
[Analysis of CHD7 gene variants in 22 patients with idiopathic hypogonadotropic hypogonadism].
Title: [Analysis of CHD7 gene variants in 22 patients with idiopathic hypogonadotropic hypogonadism].
[Clinical and genetic analysis of two patients with CHARGE syndrome due to de novo variants of CHD7 gene].
Title: [Clinical and genetic analysis of two patients with CHARGE syndrome due to de novo variants of CHD7 gene].

Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
CHARGE syndrome MedGen: C0265354 OMIM: 214800 GeneReviews: CHD7 Disorder	not available
Hypogonadotropic hypogonadism 5 with or without anosmia MedGen: C3552553 OMIM: 612370 GeneReviews: CHD7 Disorder, Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2023-04-11) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2023-04-11) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-80117 (e-PCR)
- UniSTS:102169

RH123329 (e-PCR)
- UniSTS:135706

SHGC-142634 (e-PCR)
- UniSTS:171564

SHGC-57936 (e-PCR)
- UniSTS:31291

RH94208 (e-PCR)
- UniSTS:85841

WI-11635 (e-PCR)
- UniSTS:345

RH120823 (e-PCR)
- UniSTS:133476

D8S1349E (e-PCR)
- UniSTS:151164

D8S2048 (e-PCR)
- UniSTS:64908

D8S1986 (e-PCR)
- UniSTS:30944

RH119011 (e-PCR)
- UniSTS:138979

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	TAS Traceable Author Statement more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
involved_in aorta morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular canal development	IEA Inferred from Electronic Annotation more info
involved_in blood circulation	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in cardiac septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chordate embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cranial nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cranial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epithelium development	IEA Inferred from Electronic Annotation more info
involved_in face development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female genitalia development	IEA Inferred from Electronic Annotation more info
involved_in genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nose development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb development	IEA Inferred from Electronic Annotation more info
involved_in olfactory nerve development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in right ventricular compact myocardium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semicircular canal morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in ventricular trabecula myocardium morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: chromodomain-helicase-DNA-binding protein 7

Names: ATP-dependent helicase CHD7; CHARGE association

NP_001303619.1

EC 3.6.4.12

NP_060250.2

EC 3.6.4.12

XP_011515855.1

EC 3.6.4.12

XP_011515856.1

EC 3.6.4.12

XP_011515857.1

EC 3.6.4.12

XP_011515862.1

EC 3.6.4.12

XP_016869101.1

EC 3.6.4.12

XP_016869102.1

EC 3.6.4.12

XP_047277901.1

EC 3.6.4.12

XP_047277902.1

EC 3.6.4.12

XP_047277903.1

EC 3.6.4.12

XP_054216749.1

EC 3.6.4.12

XP_054216750.1

EC 3.6.4.12

XP_054216751.1

EC 3.6.4.12

XP_054216752.1

EC 3.6.4.12

XP_054216753.1

EC 3.6.4.12

XP_054216754.1

EC 3.6.4.12

XP_054216755.1

EC 3.6.4.12

XP_054216756.1

EC 3.6.4.12

XP_054216757.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007009.1 RefSeqGene

Range

4986..194249

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_176

mRNA and Protein(s)

NM_001316690.1 → NP_001303619.1 chromodomain-helicase-DNA-binding protein 7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as CRA_e) lacks most of the internal exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is significantly shorter compared to isoform 1. This isoform, described in PMID:20925924, may negatively regulate the activity of isoform 1.

Source sequence(s)

AC113143, BC068000, BI039198, GU060498, W78145

Consensus CDS

CCDS83299.1

UniProtKB/Swiss-Prot

Q9P2D1

Related

ENSP00000437061.1, ENST00000524602.5

Conserved Domains (3) summary

smart00592
Location:593 → 637

BRK; domain in transcription and CHROMO domain helicases

pfam15991
Location:270 → 418

G_path_suppress; G-protein pathway suppressor

cl25764
Location:364 → 587

PAT1; Topoisomerase II-associated protein PAT1
NM_017780.4 → NP_060250.2 chromodomain-helicase-DNA-binding protein 7 isoform 1

See identical proteins and their annotated locations for NP_060250.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB037837, AC023102, AC113143, AK123158, BC033116, BC051264, BC068000, BI039198, W78145

Consensus CDS

CCDS47865.1

UniProtKB/Swiss-Prot

D0VBA5, E9PNZ2, Q05DI5, Q2TAN4, Q66K35, Q7Z6C0, Q7Z7Q2, Q9NXA0, Q9NXA3, Q9P2D1

Related

ENSP00000392028.1, ENST00000423902.7

Conserved Domains (9) summary

smart00592
Location:2642 → 2686

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2564 → 2604

BRK; BRK domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

60678740..60868028

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011517553.3 → XP_011515855.1 chromodomain-helicase-DNA-binding protein 7 isoform X1

See identical proteins and their annotated locations for XP_011515855.1

Conserved Domains (9) summary

smart00592
Location:2672 → 2716

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2594 → 2634

BRK; BRK domain
XM_047421945.1 → XP_047277901.1 chromodomain-helicase-DNA-binding protein 7 isoform X4
XM_011517555.3 → XP_011515857.1 chromodomain-helicase-DNA-binding protein 7 isoform X2

Conserved Domains (9) summary

smart00592
Location:2671 → 2715

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2593 → 2633

BRK; BRK domain
XM_047421946.1 → XP_047277902.1 chromodomain-helicase-DNA-binding protein 7 isoform X5
XM_017013613.2 → XP_016869102.1 chromodomain-helicase-DNA-binding protein 7 isoform X3

Conserved Domains (9) summary

smart00592
Location:2641 → 2685

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2563 → 2603

BRK; BRK domain
XM_047421947.1 → XP_047277903.1 chromodomain-helicase-DNA-binding protein 7 isoform X6
XM_011517560.3 → XP_011515862.1 chromodomain-helicase-DNA-binding protein 7 isoform X7

Conserved Domains (7) summary

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:187 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain
XM_011517554.4 → XP_011515856.1 chromodomain-helicase-DNA-binding protein 7 isoform X1

See identical proteins and their annotated locations for XP_011515856.1

Conserved Domains (9) summary

smart00592
Location:2672 → 2716

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2594 → 2634

BRK; BRK domain
XM_017013612.2 → XP_016869101.1 chromodomain-helicase-DNA-binding protein 7 isoform X1

Conserved Domains (9) summary

smart00592
Location:2672 → 2716

BRK; domain in transcription and CHROMO domain helicases

cd00024
Location:801 → 862

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

cd00046
Location:987 → 1136

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam08430
Location:306 → 423

Forkhead_N; Forkhead N-terminal region

pfam09606
Location:202 → 576

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00176
Location:971 → 1258

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1290 → 1404

Helicase_C; Helicase conserved C-terminal domain

pfam00385
Location:883 → 935

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam07533
Location:2594 → 2634

BRK; BRK domain

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

61102480..61291800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360774.1 → XP_054216749.1 chromodomain-helicase-DNA-binding protein 7 isoform X1
XM_054360779.1 → XP_054216754.1 chromodomain-helicase-DNA-binding protein 7 isoform X4
XM_054360777.1 → XP_054216752.1 chromodomain-helicase-DNA-binding protein 7 isoform X2
XM_054360780.1 → XP_054216755.1 chromodomain-helicase-DNA-binding protein 7 isoform X5
XM_054360778.1 → XP_054216753.1 chromodomain-helicase-DNA-binding protein 7 isoform X3
XM_054360781.1 → XP_054216756.1 chromodomain-helicase-DNA-binding protein 7 isoform X6
XM_054360782.1 → XP_054216757.1 chromodomain-helicase-DNA-binding protein 7 isoform X7
XM_054360776.1 → XP_054216751.1 chromodomain-helicase-DNA-binding protein 7 isoform X1
XM_054360775.1 → XP_054216750.1 chromodomain-helicase-DNA-binding protein 7 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017783.1: Suppressed sequence

Description

NM_017783.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.