Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc37a4provided by MGI
Official Full Name: solute carrier family 37 (glucose-6-phosphate transporter), member 4provided by MGI
Primary source: MGI:MGI:1316650
See related: Ensembl:ENSMUSG00000032114 AllianceGenome:MGI:1316650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G6PT; G6pt1; mG6PT; GSD-1b; 100043178
Summary: Enables glucose 6-phosphate:phosphate antiporter activity. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and hemopoiesis. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and spleen. Used to study glycogen storage disease Ia. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 71.2), liver adult (RPKM 39.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44308243..44314263)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44396946..44402966)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific reduction of G6PT may contribute to downregulation of hepatic 11beta-HSD1 in diabetic mice.
Title: Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice.
hepatic G6PT functions as an uniporter
Title: The glucose-6-phosphate transport is not mediated by a glucose-6-phosphate/phosphate exchange in liver microsomes.
Findings suggest that increased hepatic H6PDH and G6PT production contribute to 11beta-HSD1 upregulation of local glucocorticoid action that may be related to the development of type 2 diabetes.
Title: Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes.
Data suggest that G6PT may account for the metabolic flexibility that enables MSCs to survive under conditions characterized by hypoxia and could be specifically targeted within developing tumors.
Title: Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.
there is an MT1-MMP/G6PT signaling axis that regulates BMSC survival, ECM degradation, and mobilization
Title: MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival.
Glc-6-PT expression in bone marrow and neutrophils is required for normal myeloid functions
Title: Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions.
Evidence for the expression of G6PT1 in pancreatic islets.
Title: Evidence for the expression of both the hydrolase and translocase components of hepatic glucose-6-phosphatase in murine pancreatic islets.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

Slc37a4 (e-PCR), detects polymorphism
- UniSTS:547337

Slc37a4 (e-PCR), detects polymorphism
- UniSTS:526056

BB250017 (e-PCR)
- UniSTS:208368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucose 6-phosphate:phosphate antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose 6-phosphate:phosphate antiporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glucose 6-phosphate:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables glucose-6-phosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose-6-phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose-6-phosphate transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose-6-phosphate transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose-6-phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose-6-phosphate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lactate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory burst	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-6-phosphate exchanger SLC37A4

Names: glucose 6-phosphate transporter; glucose-6-phosphatase, transport protein 1; solute carrier family 37 (glycerol-6-phosphate transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293630.2 → NP_001280559.1 glucose-6-phosphate exchanger SLC37A4 isoform b

See identical proteins and their annotated locations for NP_001280559.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).

Source sequence(s)

AC122428

Consensus CDS

CCDS23108.1

UniProtKB/TrEMBL

Q6WG34, Q9D1F9

Related

ENSMUSP00000150843.2, ENSMUST00000213388.2

Conserved Domains (1) summary

cd17343
Location:10 → 417

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001293631.2 → NP_001280560.1 glucose-6-phosphate exchanger SLC37A4 isoform b

See identical proteins and their annotated locations for NP_001280560.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).

Source sequence(s)

AC122428

Consensus CDS

CCDS23108.1

UniProtKB/TrEMBL

Q6WG34, Q9D1F9

Related

ENSMUSP00000148956.2, ENSMUST00000215420.2

Conserved Domains (1) summary

cd17343
Location:10 → 417

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001357729.2 → NP_001344658.1 glucose-6-phosphate exchanger SLC37A4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (a). Variants 4-6 all encode the same isoform (a).

Source sequence(s)

AC122428

Consensus CDS

CCDS90548.1

UniProtKB/TrEMBL

A0A1L1SUI3, Q6WG34

Conserved Domains (1) summary

cd17343
Location:10 → 438

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001357730.2 → NP_001344659.1 glucose-6-phosphate exchanger SLC37A4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes the longest isoform (a). Variants 4-6 all encode the same isoform (a).

Source sequence(s)

AC122428

Consensus CDS

CCDS90548.1

UniProtKB/TrEMBL

A0A1L1SUI3, Q6WG34

Conserved Domains (1) summary

cd17343
Location:10 → 438

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378829.1 → NP_001365758.1 glucose-6-phosphate exchanger SLC37A4 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variants 4 and 5, encodes the longest isoform (a).

Source sequence(s)

AC122428

UniProtKB/TrEMBL

A0A1L1SUI3, Q6WG34

Related

ENSMUSP00000150753.2, ENSMUST00000213268.2

Conserved Domains (1) summary

cd17343
Location:10 → 438

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378830.1 → NP_001365759.1 glucose-6-phosphate exchanger SLC37A4 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variants 1-3, encodes isoform b.

Source sequence(s)

AC122428

UniProtKB/TrEMBL

Q6WG34, Q9D1F9

Conserved Domains (1) summary

cd17343
Location:10 → 417

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378831.1 → NP_001365760.1 glucose-6-phosphate exchanger SLC37A4 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform c.

Source sequence(s)

AC122428

UniProtKB/TrEMBL

Q6WG34

Conserved Domains (1) summary

cd17343
Location:20 → 409

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378832.1 → NP_001365761.1 glucose-6-phosphate exchanger SLC37A4 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform c.

Source sequence(s)

AC122428

UniProtKB/TrEMBL

Q6WG34

Conserved Domains (1) summary

cd17343
Location:20 → 409

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378833.1 → NP_001365762.1 glucose-6-phosphate exchanger SLC37A4 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform c.

Source sequence(s)

AC122428

UniProtKB/TrEMBL

Q6WG34

Conserved Domains (1) summary

cd17343
Location:20 → 409

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001378834.1 → NP_001365763.1 glucose-6-phosphate exchanger SLC37A4 isoform d

Status: VALIDATED

Source sequence(s)

AC122428

UniProtKB/TrEMBL

Q6WG34

Conserved Domains (1) summary

cd17343
Location:20 → 388

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
NM_001411170.1 → NP_001398099.1 glucose-6-phosphate exchanger SLC37A4 isoform d

Status: VALIDATED

Source sequence(s)

AC122428
NM_008063.3 → NP_032089.2 glucose-6-phosphate exchanger SLC37A4 isoform b

See identical proteins and their annotated locations for NP_032089.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).

Source sequence(s)

AC122428

Consensus CDS

CCDS23108.1

UniProtKB/TrEMBL

Q6WG34, Q9D1F9

Related

ENSMUSP00000129564.2, ENSMUST00000165839.3

Conserved Domains (1) summary

cd17343
Location:10 → 417

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44308243..44314263

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244053.2 → XP_030099913.1 glucose-6-phosphate exchanger SLC37A4 isoform X1

UniProtKB/TrEMBL

Q6WG34, Q9D1F9

Conserved Domains (1) summary

cd17343
Location:10 → 417

MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters