|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
20-409 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 556.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 20 AGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKW 99
Cdd:cd17343 40 LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 100 FEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK- 178
Cdd:cd17343 120 FSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKk 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17343 200 KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgftehEIWILVLGAVFGFSSYGPI 338
Cdd:cd17343 280 VAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSS---------------------ELFILLLGFLIGFSLYGPI 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNI 409
Cdd:cd17343 339 AIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
21-389 |
1.26e-114 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 340.12 E-value: 1.26e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGP-ILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPS---- 175
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNeepd 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 176 ----KGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAA 251
Cdd:TIGR00881 193 gdaeKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 252 GYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkdafwtpalhplaeltgfteheiWILVLGAVFG 331
Cdd:TIGR00881 273 GWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL-----------------------MDLICLFALG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 332 FSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 389
Cdd:TIGR00881 322 FLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-407 |
1.96e-88 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 272.61 E-value: 1.96e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17312 183 --------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 261 kaglsLYGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPAlhplaeltgfteHEIWILVLGAVFGFSSYGPIAL 340
Cdd:cd17312 246 -----LFGGRRAPIAVIYMLLMTLSLALF------------WFFPH------------NKLLSIVLLFLIGFFVGGPINL 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 341 FGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:cd17312 297 IGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
31-405 |
6.55e-53 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 182.60 E-value: 6.55e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 31 YAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWA 110
Cdd:PRK11663 71 YGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 111 VLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN--LDPAPSKGKKGSS 182
Cdd:PRK11663 151 IWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRHdaLELAQQQEGAGLS 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 183 KEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamaka 262
Cdd:PRK11663 231 RKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK----- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 263 glsLYGNPRHGLLLLMMAGMAASMflfrvtvtsdspkDAFWtpaLHPLAELtgfteheiwiLVLGAVF---GFSSYGPIA 339
Cdd:PRK11663 306 ---LFNGNRGPMNLIFAAGILLSV-------------GSLW---LMPFASY----------VMQAACFftiGFFVFGPQM 356
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 340 LFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWsTAFWVAEVVCGASTVVFFL 405
Cdd:PRK11663 357 LIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHW-TGFFVVISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
21-406 |
2.25e-46 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 163.35 E-value: 2.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17488 41 GILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17488 121 SRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17488 183 --------------PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 261 kaglsLYGNPRHGLLLLMMAGMAASMFLFRVTvtsdsPKDAFWTPAlhplaeltgfteheiwilVLGAVFGFSSYGPIAL 340
Cdd:cd17488 246 -----LFKGNRGPMNLIFALGLLVSVGALWLV-----PVHSYWLLA------------------TCFFTIGFFVFGPQML 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 341 FGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17488 298 IGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
21-407 |
4.63e-44 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 158.56 E-value: 4.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVF----SWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL--- 170
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIeey 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 171 --DPAPSKGKKGSSKEESTLQDL----LLSPYLWVLSTG----YLVVFGVktccTDWGQFFLIQERGQSALVGSSYISAL 240
Cdd:cd17345 201 kgDYPEEADGEEEEQELSAWEIFvkyvLKNKLLWYIAIAnvfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLF 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 241 EVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFlfrvtvtsdspkdAFWtpalhplaeltgFTEHE 320
Cdd:cd17345 277 EWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIFMILVIVALI-------------VYW------------LAPNV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 321 IWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIAKHYSWSTAFWVAEVVCGAS 399
Cdd:cd17345 324 LVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIVLLASCILA 403
|
....*...
gi 1820395068 400 TVVFFLLR 407
Cdd:cd17345 404 IIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-407 |
1.65e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 145.01 E-value: 1.65e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2271 44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFclllihnepadvglrnldpapsk 176
Cdd:COG2271 124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkkgsskeestlqdlllspYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2271 181 -------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RamakaglslYGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2271 242 R---------LGRRRKLVLAIGLLLAALALLLL-------------------------ALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
21-406 |
1.81e-28 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 116.10 E-value: 1.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSS---GLLLVGLVNVVFSW-SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:TIGR00712 64 GFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAgliLSAAVMLLMGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTM 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATI-LAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL----- 170
Cdd:TIGR00712 144 VHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIeeyrn 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 171 ---DPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGqSALVGSSYISAL-EVGGLV 246
Cdd:TIGR00712 224 dypDDYNEKAEQELTAKEIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 247 GSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFlfrvtvtsdspkdAFW-TPALHPLAEltgfteheiwiLV 325
Cdd:TIGR00712 303 GTLLCGWMSDK--------VFKGNRGATGVFFMTLVTIAVI-------------VYWmNPAGNPLVD-----------MI 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 LGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAKHYSWSTAFWVaeVVCGASTVVFF 404
Cdd:TIGR00712 351 CMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMV--MIGGSILAVIL 428
|
..
gi 1820395068 405 LL 406
Cdd:TIGR00712 429 LI 430
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-407 |
2.43e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.81 E-value: 2.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2223 39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVglrnldpapsk 176
Cdd:COG2223 119 SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2223 188 -AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2223 267 RI-----------GGRRVLLIVFALMALGLLLL-------------------------ALALGSLWLFLVLFLLLGLALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068 337 PI--ALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:COG2223 311 GGngAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-372 |
7.13e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 7.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:pfam07690 31 PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPAdvglrnldPAPSK 176
Cdd:pfam07690 111 ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--------KRPKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYG 336
Cdd:pfam07690 261 RL----------GRRRRLLLALLLLILAALGLL-----------------------LLSLTLSSLWLLLALLLLGFGFGL 307
|
330 340 350
....*....|....*....|....*....|....*.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 372
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-372 |
1.78e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.74 E-value: 1.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2814 44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldpaPSK 176
Cdd:COG2814 124 ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---------------PES 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:COG2814 269 RF-----------GRRRLLLIGLLLLALGLLLL-------------------------ALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 372
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-405 |
7.45e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.56 E-value: 7.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 15 LLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGK 94
Cdd:cd06174 28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 95 ILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ--SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDP 172
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 173 APSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd06174 188 SSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 253 YLSDRamakaglslyGNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGF 332
Cdd:cd06174 261 LLSDR----------LIGRKPLLLIGLLLMALGLALL-------------------------LLAPSLLLLLLLLLLLGF 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395068 333 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 405
Cdd:cd06174 306 GLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
21-405 |
1.23e-19 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 90.54 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW----SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:PRK11273 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTM 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSL-GPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN 169
Cdd:PRK11273 146 VHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKN 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 170 LDPA--PSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISAL-EVGGLV 246
Cdd:PRK11273 226 DYPDdyNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIP 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 247 GSIAAGYLSDRAMAkaglslyGNprhgllllmmAGMAASMFLFRVTVTSdspkDAFW-TPALHPLAELTGFTeheiwilv 325
Cdd:PRK11273 305 GTLLCGWMSDKVFR-------GN----------RGATGVFFMTLVTIAT----IVYWlNPAGNPTVDMACMI-------- 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 lgaVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlpfSTI----AKHYSWSTAFWVAEVVCGASTV 401
Cdd:PRK11273 356 ---VIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA---SAIvgytVDFFGWDGGFMVMIGGSILAVI 429
|
....
gi 1820395068 402 VFFL 405
Cdd:PRK11273 430 LLIV 433
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-406 |
1.11e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 86.86 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17319 37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnePADVGLrnldpapsk 176
Cdd:cd17319 117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQVWGL--------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkkgsskeesTLQDLLLSPYLWVLSTgylvvfgvktcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17319 185 ----------ALGYFGINYALYGLLT--------------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAMAKAglslygnpRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:cd17319 241 RLLRGA--------RRLVIIIGLLLAAVGLLLA-------------------------YLTTSPVVAVILLSLAGFGIGA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17319 288 ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-403 |
2.26e-15 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 77.28 E-value: 2.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEpadvglrnldPAPSKGK 178
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP----------PAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17475 182 ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDR- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 makaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSdspkdafwtpalhplaeltgfteHEIWILVLG-AVFGFSSYGP 337
Cdd:cd17475 261 -------VFGGRRRPVLVITAAIAAAALLVLSLLSPG-----------------------TPLWLLVLLlILLGLFAIGW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 338 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVVCGASTVVF 403
Cdd:cd17475 311 NGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-407 |
4.09e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 4.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17325 30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldPAPSK 176
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR---------PPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTvtsdspkDAFWTpalhplaeltgfteheiwILVLGAVFGFSSYG 336
Cdd:cd17325 261 RI-----------GRKPLILIGLLLSAVALLLLPLA-------TSFWL------------------LLLLLALLGLGLGL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 407
Cdd:cd17325 305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-406 |
3.03e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.59 E-value: 3.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2807 52 ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFePSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADvglrnldpapsk 176
Cdd:COG2807 132 KRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA------------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 gkKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2807 199 --AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPALHPLaeltgfteheIWILVLGAVFGFSsyg 336
Cdd:COG2807 276 RL----------GDRRPLLLLLGLLGLAGLLGL------------LLAPGSLPW----------LWAVLLGLGQGGL--- 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068 337 PIALFGVIANESAPPN----LCGTSHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVVCGASTVVFFLL 406
Cdd:COG2807 321 FPLALTLIGLRARTPAeaaaLSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-404 |
1.15e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.76 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQ--GLGWPPCGKILRK 98
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 99 WFEPSQfGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGk 178
Cdd:cd17355 121 WFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 kgsskEESTLQDLLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17355 199 -----PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 makaglslyGNPRHGLLLLMMAGMAASMFLFRVTVTSdspkdafwtpalhplaeltgfteheIWILVLGAVFGFSSYGPI 338
Cdd:cd17355 272 ---------YSPRRLLAASYALRALGLALLLLLPFPP-------------------------LALLLFAALFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 339 ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17355 318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
21-411 |
1.23e-11 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 66.22 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS-----STVSAFAALWFLNGLAQGLGWPPCGKI 95
Cdd:PRK09556 67 GMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYST 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 96 LRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLAL---SGALCVVVSFFCLLLIHNEPADVGLRN--- 169
Cdd:PRK09556 147 ITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHVIGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaee 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 170 -LDPAPSKGKKGS-----SKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVG 243
Cdd:PRK09556 227 iFGEPISEEDKETestdmTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 244 GLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDspkdafwtpalhplaeltgfteheiwI 323
Cdd:PRK09556 307 ALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTLGVYQHATSE--------------------------Y 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 324 LVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVGLMANVGGFLAGLPFSTIAKHySWS- 386
Cdd:PRK09556 351 MYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKNGTPIFGYTLT-GWAg 429
|
410 420
....*....|....*....|....*....
gi 1820395068 387 --TAFWVAEVVCGA--STVVFFLLRNIRT 411
Cdd:PRK09556 430 tfAALDIAAIGCIClmAIVAVMEERKIRR 458
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-404 |
7.38e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.34 E-value: 7.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILR 97
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 98 KwFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHnepadvglRNLDPAPSKG 177
Cdd:cd17478 111 Q-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP--------LKKPEAKKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 178 KKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17478 182 AKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 258 AMAKAglslygnprhgLLLLMMAGMAASMFLFrvtvtsdspkdaFWTPAlhplaeltgfteheIWILVLGAVFGFSSYGP 337
Cdd:cd17478 257 FGRRR-----------VIIASLLLAAPFLLLF------------LLTPG--------------IWSYILLVLAGFLLFAS 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 338 IALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17478 300 FPVTVVLAQELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-404 |
2.69e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.41 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldPAPSKGK 178
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-------------PSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 259 MAKAglslygnprhglLLLMMAGMAASMFLfrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYGPI 338
Cdd:cd17324 262 GRRA------------LLIALLLLAAALLL------------------------LTLLGPSPLLLLVGLVLWGLGFFAAH 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395068 339 ALFGVIANESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17324 306 SALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-406 |
2.16e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17474 33 PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVvSFFCLLLIHNEPadvglrnLDPAPSK 176
Cdd:cd17474 113 GDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-------KEKAKSS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17474 184 SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLT----YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAVFGFSSYG 336
Cdd:cd17474 260 KR----------FGARRILVIGLLLYALSLLLL-------------------------GFVPSLALLLIAIVLFGLGLGL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 337 PIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17474 305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-406 |
1.34e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 92 CGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSgALCVVVSFFCLLLIHNEPADVGLRNLD 171
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-ALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 172 PAPSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCtdWGQF-FLIQERGQSALVGSSYISALE-VGGLVGSI 249
Cdd:cd06173 192 LLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGAL--TVLLpLLAKEVLGGGAAGYGLLLAAFgVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 250 AAGYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeltGFTEHEIWILVLGAV 329
Cdd:cd06173 263 LLGRLSKR-----------RRRGRLLLIGALLLGLALLVL-------------------------GLSPSLWLLLAALFL 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 330 FGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd06173 307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-412 |
6.00e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 6.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 12 SCSLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 92 CGKILRkWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHnepadvglr 168
Cdd:COG0738 117 ANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL--------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 169 nldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGS 248
Cdd:COG0738 187 ---PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 249 IAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtVTSDSPKDAFWtpalhplaeltgfteheiWILVLGa 328
Cdd:COG0738 264 FLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLA---LLAPGPWLALI------------------GLALVG- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 329 vFGFSSYGPIALfgVIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRN 408
Cdd:COG0738 311 -LGLSLMFPTIF--SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKR 386
|
....
gi 1820395068 409 IRTK 412
Cdd:COG0738 387 KRRK 390
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
18-268 |
3.93e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.47 E-value: 3.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGwPPCGKILR 97
Cdd:cd17333 31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 98 KWFEPSQFGTWWAVLSTSMNLAGSLGPILAT-ILAQSYSWRSTLALSGALCVVVsfFCLLLIHNEPADVGLRNLDPAPSK 176
Cdd:cd17333 110 GALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL--AILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 177 GKKGSSKEestlqdlLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17333 188 FSASASRL-------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
250
....*....|..
gi 1820395068 257 RAMAKAGLSLYG 268
Cdd:cd17333 261 RIKPHTLLVLSG 272
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-404 |
9.47e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.62 E-value: 9.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17328 33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTII 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-YSWRSTLALSGALCVVVSFFCLLLIHNEPadvglRNldpAPS 175
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPP-----RG---AAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 176 KGKKGSSKEESTLQDL--LLS--PYLWVLSTGYLVVFGVKTCCTDWGQFFLiqeRGQSALVGSSYISALE------VGGL 245
Cdd:cd17328 185 GGVMAKSTATSFLADLkaLAKnpSFILSTLGFTAVSFVTGALAFWAPTFFL---RAFGVGDLSSADVGLIfgaitcIAGV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 246 VGSIAAGYLSDRAMAKaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKDAFWTpalhplaeltgfteheiwILV 325
Cdd:cd17328 262 LGVLLGGILADRLRRK-------TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWV------------------LLF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 326 LGAVFGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--------SWSTAFWVA 392
Cdd:cd17328 317 LGEFLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsplaeaaSLQYALLLC 393
|
410
....*....|..
gi 1820395068 393 EVVCGASTVVFF 404
Cdd:cd17328 394 SFVLVLGGFFFL 405
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
29-156 |
2.79e-05 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 46.15 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 29 AAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAF------AALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:cd17342 74 FSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGK 153
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 103 SQFGTWWAVLSTSmnlaGSLGPILATILAQS-------YSWRSTLALSGALCVVVsFFCLL 156
Cdd:cd17342 154 SSRGFVLGLWSAC----ASVGNIIGALLASSvldygyeYAFLVTSSLLFAGAIVV-FFGLL 209
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-374 |
5.32e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 14 SLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCL--------LLIHNEPADV 165
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 166 GLRNLDPAPSKGKKGSSK--EESTLQDLLLSPYLWVLSTGYL---VVFGVKTCCTDWGQFF-------LIQERGQSALVG 233
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSAlpEQKSTQGTKRSVFKALFQGKTAritVLLWLLYFMLLVGVYFltnwlpkLMVELGFSLSLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 234 SSYISALEVGGLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDspkdafwtpalhplael 313
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGAVFAVLVGSTLFSPTL----------------- 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 314 tgfteheiwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 374
Cdd:TIGR00895 341 ---------LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-179 |
7.35e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSwrSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK 178
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
|
.
gi 1820395068 179 K 179
Cdd:cd17329 194 K 194
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-158 |
1.35e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.76 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVS--AFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395068 99 WFEPSQFGtwwaVLSTSMNLAGSLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLI 158
Cdd:cd17318 139 WAPPLERS----RLTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-157 |
1.80e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG0477 48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALI 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLL 157
Cdd:COG0477 128 AELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
21-165 |
2.16e-04 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 43.07 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTvSAFAALWF------LNGLAQGLGWPPCGK 94
Cdd:cd17344 65 GALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYY-WNIHSLWYfvvvqiLAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 95 ILRKWFEPSQ----FGTWwavlstsmNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADV 165
Cdd:cd17344 144 CVGNWFGKGKrgliMGIW--------NSHTSVGNILGSLIAGifvSSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV 213
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-404 |
2.49e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 2.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17316 35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMN----LAGSLGPILATILAQSYSWRSTLALSGALCVVVsffclllihnepadvglrnldp 172
Cdd:cd17316 115 AEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRILFLIGALPALLA---------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 173 apskgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd17316 173 ------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 253 YLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGF 332
Cdd:cd17316 235 LLSDRI-----------GRKKTLVIGLILSGILALPL-----------------------FYLLSGSPTLLLLLLFILSF 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395068 333 SSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17316 281 FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-163 |
5.75e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 5.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17489 30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRStLALSGALCVVVSFFCLLLIHNEPA 163
Cdd:cd17489 110 ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIVAAVLALLALLLVFLVKDPPP 175
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-392 |
1.20e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 32 AISKFVSGVLSDQMSARW--LFSSGLLLVGLVNVVFSwSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFePSQFGtww 109
Cdd:cd17353 52 AISAPFAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG--- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 110 avLSTSMNLAG-SLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGlrNLDPAPSKGKKGSSKE 184
Cdd:cd17353 127 --LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWV--PPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 185 ESTLQDLLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17353 203 DYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 258 amakaglslYGnpRHGLLLLMMAGMAASMFLfrvtvtsdspkdafwtpalhplaeLTGFTEHEIWILVLGAVFGFSSYGP 337
Cdd:cd17353 276 ---------IG--RKNTLSIAFLIQGVAMFL------------------------LPFIGSVAVLFVLGVALIGFCYGGG 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1820395068 338 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 392
Cdd:cd17353 321 FALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
221-406 |
2.62e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtsdspkd 300
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC----------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 301 afwtpalhplaeltGFTEHEIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIA 380
Cdd:COG2814 93 --------------ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180
....*....|....*....|....*.
gi 1820395068 381 KHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
220-406 |
3.16e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.53 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 220 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTvtsdspk 299
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDR---------FGERR--VLAVGLLLMGAAALLMALV------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 300 dafwtpalhplaeltgfteHEIWILVLGAVFGFSSYGPIALFGVIA-NESAPPNLCGTSHAIVGLMANVGGFLAGLPFST 378
Cdd:cd17475 82 -------------------GSYPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPP 142
|
170 180
....*....|....*....|....*...
gi 1820395068 379 IAKHYSWSTAFWVAEVVCGASTVVFFLL 406
Cdd:cd17475 143 LALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
29-159 |
3.73e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.63 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 29 AAYAISKFVSGVLSDQMSARW------LFSSGLLLVGLVNVVFSWSSTVsaFAALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFgrkpvlLVGLFIFVLSTAMFALSSNITV--LIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395068 103 SQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIH 159
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
17-146 |
6.49e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW---SSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:cd17503 213 AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLN 292
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1820395068 94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGAL 146
Cdd:cd17503 293 TLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELL 345
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
110-404 |
7.07e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 110 AVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnldPAPSKGKKGSSKEESTLQ 189
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL--------------LPSVKPPAQKATPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 190 DLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSA-LVGS--SYISALEVgglVGSIAAGYLSDRAmakaglsl 266
Cdd:cd17471 194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395068 267 ygnprhGLLLLMMAGMAASMFLFRVTVTSDSPkdafWtpalhplaeltgfteHEIWILVLGAVFgfssYGPIALFGVIAN 346
Cdd:cd17471 263 ------GKRRLLLAGFLAGVLFYLGLALATSL----W---------------QLIALQLLNAIF----IGITAGLGISYF 313
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395068 347 ESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 404
Cdd:cd17471 314 QDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| |
