CAPRIN1 cell cycle associated protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAPRIN1provided by HGNC
Official Full Name: cell cycle associated protein 1provided by HGNC
Primary source: HGNC:HGNC:6743
See related: Ensembl:ENSG00000135387 MIM:601178; AllianceGenome:HGNC:6743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: M11S1; GPIAP1; RNG105; CONDCAC; GPIP137; GRIP137; NEDLAAD; p137GPI
Summary: Enables several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in non-membrane-bounded organelle assembly; positive regulation of stress granule assembly; and regulation of gene expression. Located in cell leading edge and cytosol. Is active in intracellular non-membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p13

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (34051731..34102610)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (34188759..34239614)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (34073278..34124157)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caprin1 Bridges PRMT1 to G3BP1 and Spaces Them to Ensure Proper Stress Granule Formation.
Title: Caprin1 Bridges PRMT1 to G3BP1 and Spaces Them to Ensure Proper Stress Granule Formation.
Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer.
Title: Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer.
CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma.
Title: CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma.
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.
Title: Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
Title: Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD.
Title: CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD.
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
Title: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma.
Title: STRESS granule-associated RNA-binding protein CAPRIN1 drives cancer progression and regulates treatment response in nasopharyngeal carcinoma.
Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1.
Title: Long noncoding RNA ZNFX1-AS1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1.
Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.
Title: Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline MedGen: C5882726 OMIM: 620636 GeneReviews: Not available	not available
Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder MedGen: CN377634 OMIM: 620782 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2024-07-24) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2024-07-24) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	HIV-1 Rev interacting protein, cell cycle associated protein 1 (CAPRIN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CAPRIN1 is increased by RRE	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142945 (e-PCR)
- UniSTS:232192

RH98715 (e-PCR)
- UniSTS:84750

WI-19568 (e-PCR)
- UniSTS:38426

RH79878 (e-PCR)
- UniSTS:86560

STS-L37771 (e-PCR)
- UniSTS:38715

RH80676 (e-PCR)
- UniSTS:91975

RH12452 (e-PCR)
- UniSTS:41299

RH123632 (e-PCR)
- UniSTS:136053

STS-T10644 (e-PCR)
- UniSTS:56961

SHGC-58520 (e-PCR)
- UniSTS:94376

RH93956 (e-PCR)
- UniSTS:84462

RH27392 (e-PCR)
- UniSTS:91644

RH64874 (e-PCR)
- UniSTS:86014

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in generation of neurons	IEA Inferred from Electronic Annotation more info
involved_in intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in non-membrane-bounded organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress granule assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in intracellular non-membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: caprin-1

Names: GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; RNA granule protein 105; activation/proliferation-associated protein 1; caprin 1; cytoplasmic activation- and proliferation-associated protein 1; cytoplasmic activation/proliferation-associated protein-1; membrane component chromosome 11 surface marker 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005898.5 → NP_005889.3 caprin-1 isoform 1

See identical proteins and their annotated locations for NP_005889.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC090469

Consensus CDS

CCDS31453.1

UniProtKB/Swiss-Prot

A6NMY7, D3DR06, Q14444, Q15074, Q6IMN4, Q6IMN7, Q9BV09

UniProtKB/TrEMBL

B3KXU8

Related

ENSP00000340329.4, ENST00000341394.9

Conserved Domains (3) summary

COG0419
Location:52 → 198

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam12287
Location:359 → 681

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:132 → 247

Caprin-1_dimer; Caprin-1 dimerization domain
NM_203364.3 → NP_976240.1 caprin-1 isoform 2

See identical proteins and their annotated locations for NP_976240.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC090469

Consensus CDS

CCDS31454.1

UniProtKB/TrEMBL

B3KXU8

Related

ENSP00000374296.3, ENST00000389645.7

Conserved Domains (3) summary

COG0419
Location:52 → 198

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam12287
Location:359 → 685

Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term

pfam18293
Location:132 → 247

Caprin-1_dimer; Caprin-1 dimerization domain