Slc4a8 solute carrier family 4 (anion exchanger), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc4a8provided by MGI
Official Full Name: solute carrier family 4 (anion exchanger), member 8provided by MGI
Primary source: MGI:MGI:1928745
See related: Ensembl:ENSMUSG00000023032 AllianceGenome:MGI:1928745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NDCBE; kNBC-3; C230026C11
Summary: Enables sodium,bicarbonate:chloride antiporter activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of intracellular pH. Located in several cellular components, including basolateral plasma membrane; neuronal cell body membrane; and presynapse. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 7.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.39 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100659628..100721852)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100761747..100823971)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

K[+]-Driven Cl[-]/HCO3[-] Exchange Mediated by Slc4a8 and Slc4a10.
Title: K(+)-Driven Cl(-)/HCO(3)(-) Exchange Mediated by Slc4a8 and Slc4a10.
Slc4a8 localizes to presynaptic nerve endings and modulates glutamate release in a pH-dependent manner.
Title: Synaptic glutamate release is modulated by the Na+ -driven Cl-/HCO₃⁻ exchanger Slc4a8.
SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Title: The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.
mouse brain exhibits marked developmental differences in the response of NDCBE protein expression to chronic continuous hypoxia
Title: Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain.
Thus, SLC4A8 is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons.
Title: Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF394701 (e-PCR)
- UniSTS:244831

AW493845 (e-PCR)
- UniSTS:180836

Slc4a8 (e-PCR), detects polymorphism
- UniSTS:508544

Slc4a8 (e-PCR), detects polymorphism
- UniSTS:546015

D15Mit97 (e-PCR), detects polymorphism
- UniSTS:127721

D15Mit97.2 (e-PCR), detects polymorphism
- UniSTS:127722

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sodium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium,bicarbonate:chloride antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium,bicarbonate:chloride antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:bicarbonate symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in basolateral protein secretion	IEA Inferred from Electronic Annotation more info
involved_in basolateral protein secretion	ISO Inferred from Sequence Orthology more info
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in asymmetric synapse	IEA Inferred from Electronic Annotation more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber	IEA Inferred from Electronic Annotation more info
located_in hippocampal mossy fiber	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
located_in symmetric synapse	IEA Inferred from Electronic Annotation more info
located_in symmetric synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electroneutral sodium bicarbonate exchanger 1

Names: electroneutral Na+-driven Cl-HCO3 exchanger; k-NBC3; solute carrier family 4 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347102.1 → NP_001334031.1 electroneutral sodium bicarbonate exchanger 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC113587, AK141910, AK171610, BP759706

Consensus CDS

CCDS84193.1

UniProtKB/Swiss-Prot

Q8JZR6

UniProtKB/TrEMBL

Q3UR07

Related

ENSMUSP00000125090.2, ENSMUST00000162049.2

Conserved Domains (1) summary

cl26877
Location:65 → 951

Band_3_cyto; Band 3 cytoplasmic domain
NM_021530.2 → NP_067505.2 electroneutral sodium bicarbonate exchanger 1 isoform 1

See identical proteins and their annotated locations for NP_067505.2

Status: VALIDATED

Source sequence(s)

AC113587, AK173014, BB626223, BB851903, BP759706

Consensus CDS

CCDS37214.1

UniProtKB/Swiss-Prot

Q3TAV7, Q6A004, Q8BYI7, Q8JZR6, Q9JKV6

Related

ENSMUSP00000023776.7, ENSMUST00000023776.13

Conserved Domains (3) summary

TIGR00834
Location:117 → 1003

ae; anion exchange protein

pfam00955
Location:443 → 956

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:145 → 402

Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

100659628..100721852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316718.2 → XP_017172207.1 electroneutral sodium bicarbonate exchanger 1 isoform X1

UniProtKB/Swiss-Prot

Q8JZR6

Conserved Domains (1) summary

cl26877
Location:65 → 951

Band_3_cyto; Band 3 cytoplasmic domain