|
| Status |
Public on May 11, 2018 |
| Title |
Single‐cell transcriptomic analysis of mouse CA1 inhibitory neurons |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We studied the transcriptomes of mouse CA1 inhibitory cells. Novel clustering methods identified all 23 previously described CA1 inhibitory types, while also suggesting 6 new inhibitory classes. Latent‐factor analysis revealed a common continuum of expression of many genes within and between classes, which we hypothesized correlates with a continuum from faster‐spiking cells that proximally target pyramidal cells, to slower active cells targeting pyramidal distal dendrites or interneurons.
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| |
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| Overall design |
6971 single cells isolated from the mouse cortex CA1 region
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| |
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| Contributor(s) |
Harris KD, Bengtsson Gonzales C, Hochgerner H, Skene NG, Magno L, Katona L, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J |
| Citation(s) |
29912866 |
| |
| Submission date |
Jun 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Sten Linnarsson |
| Organization name |
Karolinska Institutet
|
| Department |
Medical Biochemistry and Biophysics
|
| Lab |
Molecular Neurobiology
|
| Street address |
Scheeles väg 1
|
| City |
Stockholm |
| ZIP/Postal code |
171 65 |
| Country |
Sweden |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6971)
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|
| Relations |
| BioProject |
PRJNA390117 |
| SRA |
SRP109000 |
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