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| Status |
Public on Mar 13, 2018 |
| Title |
Primary osteoporosis is not reflected by disease-specific DNA methylation or accelerated epigenetic age in blood |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
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| Summary |
Osteoporosis is an age-related metabolic bone disease. Hence, osteoporotic patients might suffer from molecular features of accelerated aging, which is generally reflected by specific age-associated DNA methylation (DNAm) changes. In this study, we analyzed genome wide DNAm profiles of peripheral blood from patients with manifest primary osteoporosis and non-osteoporotic controls. Statistical analysis did not reveal any individual CG dinucleotides (CpG sites) with significant aberrant DNAm in osteoporosis. Subsequently, we analyzed if age-associated DNAm patterns are increased in OP. Using three independent age-predictors we did not find any evidence for accelerated epigenetic age in blood of osteoporotic patients. Taken together, osteoporosis is not reflected by characteristic DNAm patterns of peripheral blood that might be used as biomarker for the disease. The prevalence of osteoporosis is age-associated – but it is not associated with premature epigenetic aging in peripheral blood.
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| Overall design |
Illumina Infinium 450k Human Methylation Beadchip analysis of whole peripheral blood from primary osteoporotic patients and control individuals.
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| Contributor(s) |
Fernandez-Rebollo E, Eipel M, Seefried L, Hofmann P, Strathmann K, Jakob F, Wagner W |
| Citation(s) |
28926142 |
| |
| Submission date |
Jun 02, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Wolfgang Wagner |
| E-mail(s) |
wwagner@ukaachen.de
|
| Phone |
+49 241 8088611
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| Organization name |
RWTH Aachen University
|
| Department |
Helmholtz Institute for Biomedical Engineering
|
| Lab |
Stem Cell Biology and Cellular Engineering
|
| Street address |
Pauwelsstrasse 20
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| City |
Aachen |
| ZIP/Postal code |
52074 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA389099 |
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