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| Status |
Public on Dec 25, 2018 |
| Title |
AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (small intestinal organoid) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of AP4 were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional AP4 were compared.
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| Overall design |
AP4 deficient ApcMin/+ mice and wild-type ApcMin/+ mice were sacrificed at 16 weeks of age. 3 tumor RNA samples were obtained for each genotype; each tumor RNA sample represented a pool of 5 tumors isolated from the same mouse.
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| Contributor(s) |
Jaeckel S, Kaller M, Hermeking H |
| Citation(s) |
30177706 |
| |
| Submission date |
May 30, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Markus Kaller |
| E-mail(s) |
markus.kaller@med.uni-muenchen.de
|
| Phone |
0049-89-2180-73732
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| Organization name |
Ludwig-Maximilians-University Munich
|
| Department |
Institute of Pathology
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| Lab |
Experimental and Molecular Pathology
|
| Street address |
Thalkirchner Strasse 36
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| City |
Munich |
| ZIP/Postal code |
80337 |
| Country |
Germany |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA388453 |
| SRA |
SRP108279 |
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