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| Status |
Public on Aug 11, 2017 |
| Title |
microRNA expression profiling in diffuse malignant peritoneal mesothelioma |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Diffuse malignant peritoneal mesothelioma (DMPM) is a rapidly lethal malignancy. The comprehension of the molecular and cellular features of DMPM is of utmost importance for the fruitful management of the disease, especially in patients who fail standard treatments and have a poor prognosis due to the lack of effective alternative therapeutic options. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease. In the present study, miRNA expression profiling was carried out in a series of DMPM tissue specimens, previously characterized for the occurrence of TA, in order to possibly identify miRNAs that may play a role in the establishment/regulation of such a telomere maintenance mechanism in this malignancy and consequently furnish a biological rationale for the possible future development of miRNA-based telomerase-targeted therapeutic approaches.
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| Overall design |
microRNA expression profiling was carried out on a series of 51 frozen surgical specimens of diffuse malignant peritoneal mesothelioma (DMPM), 5 normal peritoneum samples, 1 normal mesothelial cell line (MES-F) and 1 cell line derived from the tumor of a DMPM patient.
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| Contributor(s) |
Gandellini P, Folini M |
| Citation(s) |
28716051 |
| |
| Submission date |
May 26, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Paolo Gandellini |
| E-mail(s) |
paolo.gandellini@istitutotumori.mi.it
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| Organization name |
Fondazione IRCCS Istituto Nazionale Tumori
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| Department |
Department of Applied Research and Technological Development
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| Street address |
Via Amadeo 42
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| City |
Milan |
| ZIP/Postal code |
20133 |
| Country |
Italy |
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| Platforms (1) |
| GPL8179 |
Illumina Human v2 MicroRNA expression beadchip |
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| Samples (58)
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| Relations |
| BioProject |
PRJNA388196 |
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