|
| Status |
Public on Apr 18, 2018 |
| Title |
Differential Gene Expression and Pathway Analysis in Juvenile Nasopharyngeal Angiofibroma Using RNA-Sequencing |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have identified a set of differentially expressed genes in the juvenile nasopharyngeal angiofibroma transcriptome and predict activation of the vascular endothelial growth factor and interleukin-6 signaling pathways, which represent potential molecular targets for therapy in patients with inoperable or persistent disease. These results implicate the role of fibroblasts as a tumor cell type driving disease progression.
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| |
|
| Overall design |
mRNA transcriptome profiles of cultured fibroblasts from two juvenile nasopharyngeal angiofibroma tumor explants and two fibroblast replicates cultured from normal adult tonsil tissue
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| |
|
| Contributor(s) |
Jones JW, New J, Gunewardena S, Thomas SM |
| Citation(s) |
29634432 |
| |
| Submission date |
May 24, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Sufi Mary Thomas |
| E-mail(s) |
sthomas7@kumc.edu
|
| Organization name |
University of Kansas Medical Center
|
| Department |
Otolaryngology-Head & Neck Surgery
|
| Lab |
4031 Wahl Hall East
|
| Street address |
3901 Rainbow Blvd. Mail Stop 4031
|
| City |
Kansas City |
| State/province |
Kansas |
| ZIP/Postal code |
66160 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (4)
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|
| Relations |
| BioProject |
PRJNA387701 |
| SRA |
SRP107936 |
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