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Series GSE98843 Query DataSets for GSE98843
Status Public on Mar 14, 2018
Title Epigenome analysis reveals novel aspects of ILC2 activation and supports a pathogenic role in asthma
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Recent studies have shown that group 2 innate lymphoid cells (ILC2s) can drive eosinophilic airway inflammation in mouse models of asthma. Moreover, elevated ILC2 counts and/or activity have been reported in asthmatics, together suggesting that ILC2s play an important role in asthma pathophysiology. However, many aspects of ILC2 biology are not fully understood, including the mechanisms underlying ILC2 activation, the tissue-specific functions of ILC2s during inflammation (e.g. lung versus draining lymph node) and what drives ILC2 plasticity. Importantly, it is unknown whether human (epi)genetic variation associated with asthma susceptibility and persistence can be coupled to ILC2s. We address these questions in our manuscript by studying the epigenome of murine ILC2s obtained from Gata3-reporter mice with eosinophilic airway inflammation as well as human ILC2s obtained from peripheral blood and activated in vitro.
Overall design biological replicate (n=2-4) RNA-Seq and ChIPmentation experiments including negative controls
Contributor(s) Stadhouders R, Hendriks RW
Citation(s) 29486229
Submission date May 11, 2017
Last update date Jul 25, 2021
Contact name Ralph Stadhouders
Organization name Erasmus Medical Center
Department Pulmonary Medicine
Street address Dr. Molewaterplein 50
City Rotterdam
ZIP/Postal code 3015 GE
Country Netherlands
Platforms (3)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (15)
GSM2616171 k4m2_ILC2_BAL1
GSM2616172 k4m2_ILC2_BAL2
GSM2616173 k4m2_ILC2_MLN1
BioProject PRJNA386379
SRA SRP106918

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Supplementary file Size Download File type/resource
GSE98843_RAW.tar 5.8 Mb (http)(custom) TAR (of BED, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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