 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Nov 13, 2017 |
| Title |
Therapeutic Inhibition of Inflammatory Monocyte Recruitment Reduces Steatohepatitis and Liver Fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The CCR2/CCR5 inhibitor cenicriviroc blocks infiltration of inflammatory monocytes into the liver, thereby reducing NASH progression and fibrosis.
|
| |
|
| Overall design |
The study demonstrates the hepatic accumulation of inflammatory CCR2+ macrophages in patients with NASH fibrosis and reveals that the dual CCR2/CCR5 inhibitor CVC effectively ameliorates steatohepatitis and fibrosis in mouse models by inhibiting the infiltration of monocytes during chronic liver injury. Thus, this study provides functional evidence for the successful therapeutic targeting of monocyte recruitment in steatohepatitis and fibrosis, mandating the clinical development of CCR2/CCR5 inhibitors in patients with NASH.
|
| |
|
| Contributor(s) |
Krenkel O, Puengel T, Govaere O, Abdallah AT, Mossanen JC, Kohlhepp M, Liepelt A, Lefebvre E, Luedde T, Hellerbrand C, Weiskirchen R, Longerich T, Costa IG, Anstee QM, Trautwein C, Tacke F |
| Citation(s) |
28940700 |
| |
| Submission date |
May 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Ali T Abdallah |
| E-mail(s) |
bioinformatics.ali.abdallah@gmail.com
|
| Organization name |
University of Cologne
|
| Department |
Medical Faculty
|
| Lab |
CECAD
|
| Street address |
Joseph Stelzmann Str. 26
|
| City |
Cologne |
| ZIP/Postal code |
50931 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA386193 |
| SRA |
SRP106814 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE98782_TreatedKC_UntreatedKC.xlsx |
6.9 Mb |
(ftp)(http) |
XLSX |
| GSE98782_TreatedMO_TreatedKC.txt.gz |
489.0 Kb |
(ftp)(http) |
TXT |
| GSE98782_TreatedMO_TreatedKC.xlsx |
7.2 Mb |
(ftp)(http) |
XLSX |
| GSE98782_TreatedMO_UntreatedMO.xlsx |
9.1 Mb |
(ftp)(http) |
XLSX |
| GSE98782_UntreatedMO_UntreatedKC.xlsx |
9.5 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...