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| Status |
Public on May 30, 2017 |
| Title |
DNA methylation profiling of human prefrontal cortex neurons in heroin users shows significant difference between genomic contexts of hyper- and hypomethylation and a younger epigenetic age |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
Illumina 450K Infinium microarray profiling of DNA methylation in FACS-separated neuronal nuclei from the postmortem orbitofrontal (OF) cortex of heroin users, controls and sucide individuals.
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| |
|
| Overall design |
Genomic DNA was isolated from FACS-sorted human brain neuronal nuclei. DNA was bisulfite-converted and hybridized to the Illumina Infinium 450K Human Methylation Beadchip array. 88 subjects were analyzed.
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| |
|
| Contributor(s) |
Kozlenkov A, Dracheva S |
| Citation(s) |
28556790 |
| |
| Submission date |
Apr 25, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Stella Dracheva |
| E-mail(s) |
stella.dracheva@mssm.edu
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Department |
Dept. of Psychiatry
|
| Street address |
James J. Peters VA Medical Center,130 W Kingsbridge Rd
|
| City |
Bronx |
| State/province |
New York |
| ZIP/Postal code |
10468 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
|
| Samples (88)
|
|
| Relations |
| BioProject |
PRJNA384247 |
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