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Series GSE98101 Query DataSets for GSE98101
Status Public on Oct 07, 2019
Title Spatial-temporal epigenetic landscape of mouse gastrula
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Summary Regionalized lineage progenitor cells emerged from the onset of gastrulation would facilitate mouse embryonic patterning and build a blueprint for future development. However, the molecular mechanism especially the epigentic mechanism underlying the formation and development of lineage restricted cells has not been fully unveiled. Here,we present a comprehensive landscape of H3K4me3, H3K4me1, H3K9ac, H3K27ac, H3K27me3 and DNA methylation pattern in mouse embryo from pre-streak stage to late-streak stage, and fully analyze the epigenetic mechansim driving the embryonic patterning of mouse gastrula
Overall design To obtain a comprehensive epigenetic landscape of mouse gastrulation and the corresponding lineage development process, we have dissected mouse gastrula from pre-steak stage (E6.5) to late streak stage (E7.5)19 into extra-embryonic (ExE) and embryonic parts, and embryonic parts of E7.0 and E7.5 embryos will be further divided into sub-regions (A, P, AM) due to the emergence of embryo asymmetry.
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Contributor(s) Yang X, Hu B, Hou Y, Qiao Y, Tang F, Jiang N
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Apr 24, 2017
Last update date Jul 25, 2021
Contact name Naihe Jing
Organization name shanghai institute of biochemistry and cell biology
Street address Yueyang Road 320
City Shanghai City
ZIP/Postal code 200031
Country China
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (120)
GSM2587123 E6-5-Epi-INPUT
GSM2587124 E6-5-Epi-INPUT_rep2
GSM2587125 E6-5-ExE-INPUT
BioProject PRJNA384051
SRA SRP105106

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource 1.1 Gb (ftp)(http) BW 625.9 Mb (ftp)(http) BW 1.3 Gb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 602.1 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 1020.1 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 507.2 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 947.1 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 568.4 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 660.1 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 911.3 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 1019.1 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 1.0 Gb (ftp)(http) BW 434.7 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 896.3 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 648.2 Mb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 1.2 Gb (ftp)(http) BW 652.7 Mb (ftp)(http) BW 1.1 Gb (ftp)(http) BW 1.1 Gb (ftp)(http) BW
GSE98101_Enh9E_KO-merge.dexseq_clean_refseq.gene.txt.gz 342.5 Kb (ftp)(http) TXT
GSE98101_RAW.tar 3.4 Gb (http)(custom) TAR (of BW, TAGALIGN)
GSE98101_merge.dexseq_clean_refseq.gene.all.xls.gz 659.2 Kb (ftp)(http) XLS
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Processed data provided as supplementary file
Raw data are available in SRA
Processed data are available on Series record

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