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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 22, 2008 |
| Title |
Gene Profiling in the Livers of Wild-Type and PPARalpha-Null Mice Exposed to Perfluorooctanoic Acid (PFOA) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Unlike the PPARalpha agonist W14,643, PFOA is capable of inducing effects independently of PPARa. Genes altered in the PPARalpha-null mouse following exposure to PFOA included those associated with fatty acid metabolism, inflammation, xenobiotic metabolism, and cell cycle progression. The specific signaling pathway(s) responsible for these effects is not readily apparent but it is conceivable that other members of the nuclear receptor superfamily such as PPARbeta/delta and CAR may be involved.
Keywords: dose response
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| Overall design |
Wild-type and PPARa-null mice were orally dosed for 7 days with either PFOA (1 or 3 mg/kg), the PPARalpha agonist WY-14,643 (50 mg/kg), or compound vehicle. Gene profiling analysis was conducted on 4 animals per group using Applied Biosystems Mouse Genome Survey Microarrays.
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| Contributor(s) |
Rosen MB, Abbott BD, Wolf DC, Corton JC, Wood CR, Schmid JE, Das KP, Zehr RD, Blair ET, Lau C |
| Citation(s) |
18467677 |
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| Submission date |
Dec 05, 2007 |
| Last update date |
Mar 17, 2012 |
| Contact name |
Mitchell B Rosen |
| E-mail(s) |
rosen.mitch@epa.gov
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| Phone |
919-541-2223
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| Fax |
919-541-4017
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| Organization name |
U.S. EPA
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| Department |
Reproductive Toxicology
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| Lab |
GEEBB
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| Street address |
2525 Hwy 54
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| City |
Research Triangle Park |
| State/province |
NC |
| ZIP/Postal code |
27711 |
| Country |
USA |
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| Platforms (1) |
| GPL2995 |
ABI Mouse Genome Survey Microarray |
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| Samples (39)
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| GSM247343 |
wild-type+ 0.5% methylcellulose, rep1 |
| GSM247344 |
PPARa-null+0mg/kg PFOA, rep1 |
| GSM247345 |
PPARa-null+1mg/kg PFOA, rep1 |
| GSM247346 |
PPARa-null+0.5% methylcellulose, rep1 |
| GSM247347 |
wild-type+0mg/kg PFOA, rep1 |
| GSM247348 |
wild-type+3mg/kg PFOA, rep1 |
| GSM247349 |
PPARa-null+50mg/kg Wy14,643, rep1 |
| GSM247350 |
PPARa-null+3mg/kg PFOA, rep2 |
| GSM247351 |
PPARa-null+1mg/kg PFOA, rep2 |
| GSM247352 |
wild-type+ 0.5% methylcellulose, rep2 |
| GSM247353 |
wild-type+3mg/kg PFOA, rep2 |
| GSM247354 |
PPARa-null+0.5% methylcellulose, rep2 |
| GSM247355 |
wild-type+0mg/kg PFOA, rep2 |
| GSM247356 |
wild-type+50mg/kg Wy14,643, rep2 |
| GSM247357 |
wild-type+1mg/kg PFOA, rep2 |
| GSM247358 |
PPARa-null+50mg/kg Wy14,643, rep2 |
| GSM247359 |
wild-type+ 0.5% methylcellulose, rep3 |
| GSM247360 |
PPARa-null+1mg/kg PFOA, rep3 |
| GSM247361 |
PPARa-null+0mg/kg PFOA, rep2 |
| GSM247362 |
wild-type+1mg/kg PFOA, rep3 |
| GSM247363 |
wild-type+3mg/kg PFOA, rep3 |
| GSM247364 |
PPARa-null+3mg/kg PFOA, rep3 |
| GSM247365 |
PPARa-null+50mg/kg Wy14,643, rep3 |
| GSM247366 |
wild-type+0mg/kg PFOA, rep3 |
| GSM247367 |
PPARa-null+0.5% methylcellulose, rep3 |
| GSM247368 |
wild-type+50mg/kg Wy14,643, rep3 |
| GSM247369 |
PPARa-null+50mg/kg Wy14,643, rep4 |
| GSM247370 |
PPARa-null+0mg/kg PFOA, rep3 |
| GSM247371 |
PPARa-null+0mg/kg PFOA, rep4 |
| GSM247372 |
wild-type+3mg/kg PFOA, rep4 |
| GSM247373 |
PPARa-null+1mg/kg PFOA, rep4 |
| GSM247374 |
wild-type+1mg/kg PFOA, rep4 |
| GSM247375 |
PPARa-null+0.5% methylcellulose, rep4 |
| GSM247376 |
PPARa-null+3mg/kg PFOA, rep4 |
| GSM247377 |
wild-type+0mg/kg PFOA, rep4 |
| GSM247378 |
wild-type+50mg/kg Wy14,643, rep4 |
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| Relations |
| BioProject |
PRJNA103737 |
| Supplementary data files not provided |
| Processed data included within Sample table |
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