|
| Status |
Public on Aug 02, 2017 |
| Title |
DNA Methylation of Synaptic Genes in the Prefrontal Cortex is Associated with Aging and Age-Related Cognitive Impairment |
| Organism |
Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
This study investigated the epigenetic mark of DNA methylation in the medial prefrontal cortex (mPFC) as a function of age and cognition. Young and aged F344 rats were characterized in a cognitive flexibility task, set shifting, and whole-genome bisulfite sequencing was performed in an Illumina system.
The results indicate that differential methylation was linked to the expression of genes within functional categories which may mediate impaired cognition in aging. Differences in aging included hypermethylation of genes linked to synaptic function and GTPase activity. Further, age-related cognitive flexibility impairment was correlated to hypermethylation of synaptic, postsynaptic density and ion channel activity genes.
|
| |
|
| Overall design |
The study contains 10 young and 20 aged rats utilized to investigate the epigenetic alterations in the mPFC associated to aging and executive function.
|
| |
|
| Contributor(s) |
Ianov L, Riva A, Kumar A, Foster TC |
| Citation(s) |
28824413 |
| |
| Submission date |
Apr 10, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Thomas C Foster |
| E-mail(s) |
foster1@ufl.edu
|
| Organization name |
University of Florida-McKnight Brain Institute
|
| Department |
Neuroscience
|
| Lab |
Foster
|
| Street address |
1149 Newell Drive Bldg 59
|
| City |
Gainesville |
| State/province |
Florida |
| ZIP/Postal code |
32611 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA382428 |
| SRA |
SRP103785 |
Less...
More...