|
| Status |
Public on Dec 31, 2019 |
| Title |
Genome-wide mRNA expression profiling of WT MEFs and NSD2 KO MEFs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
NSD2 (also known as Whsc1, MMSET) play a role in H3K36 methyl transferase. Here we showed that 199 ISGs of the total 393 ISGs after 2h IFN treatment were up regulated in NSD2 KO MEFs, suggesting negatively regulate ISGs induction. IFN pretreatment creates transcriptional memory. In this study we identified 129 ISGs were memory ISGs and 40 ISGs were non-memory ISGs.
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| |
|
| Overall design |
RNA-seq WT MEFs and NSD2 KO MEFs
|
| |
|
| Contributor(s) |
Ouda R, Bachu M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 31, 2017 |
| Last update date |
Jan 01, 2020 |
| Contact name |
Mahesh Bachu |
| E-mail(s) |
bmahesh07@gmail.com, bachum@hss.edu
|
| Organization name |
Hospital For Special Surgery
|
| Street address |
535 E 70th St 6th Floor
|
| City |
New York |
| State/province |
New York |
| ZIP/Postal code |
10021 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (15)
|
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| This SubSeries is part of SuperSeries: |
| GSE97280 |
NSD2 negatively regulate innate immune response through Zmynd11 |
|
| Relations |
| BioProject |
PRJNA381196 |
| SRA |
SRP102785 |
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