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| Status |
Public on Jan 22, 2021 |
| Title |
Aberrant lncRNA expression profiles in OSCC plasma |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
Expression profiling by array
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| Summary |
Carcinogenesis is a genetic process in which molecular changes occur earlier than histomorphological changes. The key to early detection of oral squamous cell carcinoma (OSCC) is to identify genetic alterations. However, aberrant lncRNA expression profiles in OSCC plasma is still largely unknown. Using an lncRNA microarray, we analyzed the aberrant lncRNA expression profiles in OSCC plasma compared with paired healthy volunteer plasma. Our data revealed 7473 differentially expressed (Fold Change >= 2.0, P-value <= 0.05) lncRNAs, among which 3972 lncRNAs were significantly up-regulated and 3501 lncRNAs were down-regulated in OSCC compared with paired healthy volunteer plasma.
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| Overall design |
Plasma was obtained from 3 healthy adult volunteers and 3 patients with OSCC. LncRNA expression profiles were evaluated by an Agilent Human LncRNA Array v4.0 (8 x 60K, Arraystar).
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| Contributor(s) |
Jia H, Wang X, Sun Z |
| Citation(s) |
33552289 |
|
https://doi.org/10.3892/ol.2021.12433
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| |
| Submission date |
Mar 30, 2017 |
| Last update date |
Feb 23, 2021 |
| Contact name |
Hongcheng Jia |
| E-mail(s) |
jiahongcheng@ccmu.edu.cn
|
| Phone |
+861084322903
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| Organization name |
Beijing Ditan Hospital, Capital Medical University
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| Department |
Stomatology Department
|
| Street address |
No.8 East Jing Shun Rd, Chaoyang District
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| City |
Beijing |
| State/province |
Beijing |
| ZIP/Postal code |
100015 |
| Country |
China |
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| Platforms (1) |
| GPL21827 |
Agilent-079487 Arraystar Human LncRNA microarray V4 (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA381083 |
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