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| Status |
Public on Mar 30, 2017 |
| Title |
Gene expression profile during cardiac stress induced by transverse aortic constriction (TAC) and myocardial infarction (MI) with or without BET protein inhibitor JQ1 in mouse hearts |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose: to reveal cardiac stress-inducible genes that are attnuated by BET inhibition
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| Overall design |
Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to sham surgery and received vehicle injection for 6 weeks starting post-op week 4.
Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to TAC surgery with a 27 gauge needle. Starting at the beginning of post-op week 4, JQ1 at 50 mg/kg/d was adminstrated via I.P. injections and continue for another 6 weeks.
Method: Adult C57Bl/6 mice (male, 10 wks) were subjected to Permanent Ligation of the Left Anterior Descending Coronary Artery. Beginning from post-op day 6, JQ1 at 25 mg/kg/d or vehcle was given via I.P. for 6 days and then increased to 50 mg/kg/d for additional 16 days.
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| Contributor(s) |
Duan Q, Lemieux M, McMahon S, Anand P, Haldar S |
| Citation(s) |
28515341 |
| |
| Submission date |
Mar 13, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Saptarsi Haldar |
| E-mail(s) |
saptarsi.haldar@gladstone.ucsf.edu
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| Organization name |
Gladstone Institute of Cardiovascular Disease
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| Street address |
1650 Owens St
|
| City |
San Francisco |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA379048 |
| SRA |
SRP101884 |
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