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Series GSE95726 Query DataSets for GSE95726
Status Public on Jun 06, 2018
Title Copy number profiling of prostate cancers from 40 African American patients
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary African American (AA) men have a significantly higher mortality rate from prostate cancer (PCa) compared to European American (EA) men. AA men are twice as likely to die from PCa compared to EA men and 8 times as likely as Asian American men to die from PCa. The biological basis for these differences in PCa mortality are unclear. We carried out Copy Number Alteration (CNA) studies on a new set of 40 highly tumor-enriched primary PCas and matched benign prostate tissues from AA men using high resolution Affymetrix 6.0 SNP arrays and expression array analysis using RNAs (GSE71016) from the same tissues using high purity tumors from AA men and matched benign tissue. We have confirmed the specific loss of 4p16.3 described previously and identified a novel tumor suppressor gene, RGS12 at this locus that shows significantly decreased expression in AA PCa but not EA EA PCa.
Overall design Profiles were generated on Affymetrix SNP 6.0 chips. In all, 40 tumors and 40 paired normal samples were profiled, 40 profiles in all. Each tumor was centered on its corresponding normal pair to define copy number alterations (CNA) in that tumor.
Contributor(s) Ittamann M, Zhang Y, Creighton C
Citation(s) 28611045
Submission date Mar 06, 2017
Last update date Nov 27, 2018
Contact name Chad Creighton
Organization name Baylor College of Medicine
Department Biostatistics, Ducan Cancer Center
Street address One Baylor Plaza, Mail Stop: BCM305
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (80)
GSM2522842 Cancer_1199
GSM2522843 Normal_1199
GSM2522844 Cancer_1298
BioProject PRJNA378237

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE95726_RAW.tar 2.2 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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