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Series GSE95685 Query DataSets for GSE95685
Status Public on Jul 14, 2017
Title RNA-seq analysis of mouse liver transcriptome following exposure to TCPOBOP or PCN
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Changes in gene expression were assayed in mouse liver nuclear RNA following a single injection of the CAR agonist TCPOBOP (1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene) or the PXR agonist PCN (pregnenolone 16α-carbonitrile) in 7-week old mice. This study is part of a larger study entitled Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver (PMID: 28903501).
 
Overall design Nuclear RNA was isolated from male and female CD1 mouse liver following either 3 hour exposure or 27 hour exposure to TCPOBOP; or from male liver following a 3 hour exposure to PCN. N=2-3 biological pools were sequenced per control or treatment group, with each pool comprised of nuclear RNA pooled from n=3-4 individual mouse livers.
 
Contributor(s) Lodato NJ, Waxman DJ
Citation(s) 28903501
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 ES024421 Epigenetic Actions of Environmental Chemicals BOSTON UNIVERSITY CHARLES RIVER CAMPUS DAVID J WAXMAN
Submission date Mar 03, 2017
Last update date May 15, 2019
Contact name David J. Waxman
E-mail(s) djw@bu.edu
Organization name Boston University
Department Department of Biology and Bioinformatics Program
Street address 5 Cummington Mall
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (22)
GSM2521616 Male liver 3 h vehicle_pool1 (control for TCPOBOP treatments)_G123_M1
GSM2521617 Male liver 3 h vehicle_pool2 (control for TCPOBOP treatments)_G123_M2
GSM2521618 Male liver 3 h TCPOBOP_pool1_G123_M3
Relations
BioProject PRJNA377914
SRA SRP101363

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Supplementary file Size Download File type/resource
GSE95685_G95_G123_DiffExp_RefSeq_Male_Female_TCPOBOP_PCN.xlsx 6.4 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record
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