|
| Status |
Public on Mar 18, 2019 |
| Title |
Differential gene expression in IDH1-R132H Low Grade Glioma animal brain tumors brain in response to 10 Gy of radiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
IDH1-R132H is expressed in Low Grade Glioma (LGG) in combination with loss of function mutation in ATRX and TP53 genes. IDH1-R132H results in gain of function with production
of 2-hydroxygluatrate, that in turn generates a hypermethylatyed phenotype in DNA and histone with consequences in epigenetic regulation of gene expression. Here we will
compare the gene expression profile between IDH1-R132H and IDH1 Wt LLG animal brain tumors in reponse to radiation
|
| |
|
| Overall design |
Evaluate differential gene expression between Brain DH1-R132H and IDH1 wt in response to 10Gy ionizing radiation at 14 days after tumor neurospheres implantation
|
| |
|
| Contributor(s) |
McEachin R, Nunez FJ, Castro MG, Lowenstein PR |
| Citation(s) |
30760578 |
| |
| Submission date |
Feb 16, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Richard C McEachin |
| E-mail(s) |
mceachin@umich.edu
|
| Organization name |
University of Michigan
|
| Department |
DCM&B
|
| Street address |
2800 Plymouth Road
|
| City |
Ann Arbor |
| State/province |
United States |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (16)
|
|
| This SubSeries is part of SuperSeries: |
| GSE94976 |
IDH1-R132H Low Grade Glioma animal brain tumors |
|
| Relations |
| BioProject |
PRJNA375076 |
| SRA |
SRP100060 |
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