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| Status |
Public on Apr 03, 2017 |
| Title |
Gene expression in rat striatum following carbon monoxide poisoning and hypoxic hypoxia |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
We have proposed the existence of a threshold for brain damage, in terms of hydroxyl radical production in rat striatum, between poisoning of carbon monoxide (CO) at 1000 ppm and 3000 ppm, where blood CO-hemoglobin levels reach approximately 50% and over 70%, respectively. To search for factors involved in brain damage, we examined the effects of air, 1000 ppm CO, 3000 ppm CO and 5% O2 (hypoxic conditions comparable with those by 3000 ppm CO) on gene expression in rat striatum, using microarray analysis.
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| Overall design |
Gene expression was measured in rat striatum which had been obtained at 0, 2, 6, or 12 hours after the 40-minute exposure to air, 1000 ppm CO, 3000 ppm CO or 5% O2 (a rat for each time of each exposure). The control is 0 hour after air.
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| Contributor(s) |
Hara S, Kuriiwa F, Kobayashi M, Mizukami H |
| Citation |
Shuichi Hara, Masamune Kobayash, Fumi Kuriiwa, Kunihiko Kurosaki, and Hajime Mizukami. Gene expression in rat striatum following carbon monoxide poisoning. Genomics Data 2017;12:74-75. doi: 10.1016/j.gdata.2017.03.007
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| Submission date |
Feb 10, 2017 |
| Last update date |
Apr 03, 2017 |
| Contact name |
Shuichi Hara |
| E-mail(s) |
s-hara@tokyo-med.ac.jp
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| Organization name |
Tokyo Medical University
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| Department |
Forensic Medicine
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| Street address |
6-1-1 Shinjuku, Shinjuku-ku
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| City |
Tokyo |
| ZIP/Postal code |
160-8402 |
| Country |
Japan |
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| Platforms (1) |
| GPL7294 |
Agilent-014879 Whole Rat Genome Microarray 4x44K G4131F (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA374034 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE94780_RAW.tar |
106.9 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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