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Series GSE93777 Query DataSets for GSE93777
Status Public on Jul 16, 2018
Title Multi-omics monitoring of drug response in rheumatoid arthritis.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This SuperSeries is composed of the SubSeries listed below.

Sustained clinical remission (CR) without drug treatment has not been achieved in patients with rheumatoid arthritis (RA). This implies a substantial difference between CR and the healthy state, but it has yet to be quantified. We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data reveal that drug treatments alter the molecular profile closer to that of HCs at the transcriptome, serum proteome and immunophenotype level. Patient follow-up suggests that the molecular profile after drug treatments is associated with long-term stable CR. In addition, we identify molecular signatures that are resistant to drug treatments. These signatures are associated with RA independently of known disease severity indexes and are largely explained by the imbalance of neutrophils, monocytes, and lymphocytes. This high-dimensional phenotyping provides a quantitative measure of molecular remission and illustrates a multi-omics approach to understanding drug response.
 
Overall design Refer to individual Series

Transcriptome of whole blood and sorted immune cells from patients with or without drug treatments (methotrexate, infliximab, and tocilizumab) and healthy volunteers. Serum proteins measured by SOMAscan and peripheral immune cell counts were also measured for the same blood samples and can be found at http://dx.doi.org/10.7303/syn8483403 .
 
Citation(s) 30013029
Submission date Jan 18, 2017
Last update date Mar 25, 2019
Contact name Shinya Tasaki
Organization name Takeda Pharmaceutical Company Limited
Street address 26-1, Muraoka-Higashi 2-chome
City Fujisawa
State/province Kanagawa
ZIP/Postal code 251-8555
Country Japan
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (448)
GSM2449608 Whole blood from healthy control(HC003_1)
GSM2449609 Whole blood from healthy control(HC004_1)
GSM2449610 Whole blood from healthy control(HC005_1)
This SuperSeries is composed of the following SubSeries:
GSE93272 Whole blood gene expression of rheumatoid arthritis
GSE93776 Immune cells gene expression from rheumatoid arthritis and healthy donors
Relations
BioProject PRJNA362343

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93777_RAW.tar 2.4 Gb (http)(custom) TAR (of CEL)

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