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| Status |
Public on Sep 21, 2017 |
| Title |
Proteogenomic characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC).
Here, we present an integrated analysis of transcriptomes and proteomes generated from wild-type and TSC1/Emx1-Cre forebrains.
This led to comprehensive lists of genes and proteins whose expression levels were altered by hyperactivated mTOR signaling.
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| Overall design |
Comparative analyses of data from wild-type (WT) and TSC1/Emx1-Cre forebrains revealed sets of genes and proteins altered by TSC1 knockout.
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| Contributor(s) |
Shin J, Kim M, Jung H, Cha HL, Suh-Kim H, Ahn S, Jung J, Kim Y, Jun Y, Lee S, Hwang D, Kim J |
| Citation(s) |
28588230 |
| |
| Submission date |
Jan 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Yukyung Jun |
| E-mail(s) |
yellow9250@gmail.com
|
| Organization name |
Korea Institute of Science and Technology Information
|
| Department |
Center for Supercomputing Applications
|
| Street address |
245 Daehak-ro, Yuseong-gu
|
| City |
Daejeon |
| ZIP/Postal code |
34141 |
| Country |
South Korea |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA360611 |
| SRA |
SRP096336 |
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