|
| Status |
Public on Mar 30, 2019 |
| Title |
AMPK signaling for naïve pluripotency [Hs] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We show activation of AMP kinase (AMPK) with single chemical compounds can endow naïve pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to naïve state. Moreover, AMPK activators reverted human ESCs to naïve state with pluripotent gene expression profiles and X-chromosome reactivation.
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| |
|
| Overall design |
We analyzed gene expression profiles of human ESCs with AICAR during differentiation and reversion
|
| |
|
| Contributor(s) |
Yamashita JK, Liu Y, Takashima Y, Yang Z, Watanabe A, Mizoro Y, Okada C, Nakamura M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 22, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Akira Watanabe |
| E-mail(s) |
a.watanabe@cyberomix.com
|
| Organization name |
CyberomiX Inc
|
| Street address |
Rm504, Miyako Bldg, 233, Isa-cho, kamigyo-ku
|
| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
602-8407 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE92726 |
AMPK signaling for naïve pluripotency |
|
| Relations |
| BioProject |
PRJNA358469 |
| SRA |
SRP095513 |
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