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| Status |
Public on Mar 01, 2017 |
| Title |
Transcriptome analysis for KDM6A mutated urothelial bladder carcinoma and EZH2 inhibitor treated KDM6A mutated urothelial bladder carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: The goals of this study are to compare 1. The transcription profile in KDM6A wildtype and KDM6A mutated urothelial bladder carcinoma. 2. The transcriptional changes in KDM6A mutated urothelial bladder carcinoma upon EZH2 inhibitor treatment.
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| Overall design |
Transcriptome profiling of KDM6A wildtype and KDM6A mutated urothelial bladder carcinoma were generated by deep sequencing, 10 cases in each group, using Hiseq2000.
Transcriptome profiling of EZH2 inhibitor-treated KDM6A wildtype and KDM6A mutated urothelial bladder carcinoma were generated by deep sequencing, in triplicate, using Hiseq2000.
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| |
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| Contributor(s) |
Ler LD, Teh BT |
| Citation(s) |
28228601 |
| |
| Submission date |
Dec 21, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Xiaoran Chai |
| E-mail(s) |
chaix@gis.a-star.edu.sg
|
| Organization name |
Genome Institute of Singapore
|
| Street address |
60 Biopolis Street, Genome, #02-01
|
| City |
Singapore |
| State/province |
Singapore |
| ZIP/Postal code |
138672 |
| Country |
Singapore |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (50)
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| Relations |
| BioProject |
PRJNA358425 |
| SRA |
SRP095491 |
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