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| Status |
Public on Jan 31, 2017 |
| Title |
Advax, a delta inulin microparticle, potentiates in-built adjuvant property of co-administered vaccines |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression data from mouse organs after Advax injection
Advax, an inulin-derived microparticle, has been developed as an adjuvant for several vaccines. Advax is a unique class of adjuvant which can potentiate the endogenous adjuvant effect of the vaccines through a not yet fully-identified, unique mechanisms of action.
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| Overall design |
C57BL/6J mice (6 week old, male, n = 2 or 3) were injected i.d. or i.p. with a total volume of 1000ug of Advax in PBS. The vehicle-control mice (n = 2 or 3) were injected with the same volume of PBS. After 6 h, the inguinal LNs, liver, kidney and spleen were removed (within one hour for all samples) and grobal gene expression was obtained by Affymetrix GeneChip.
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| Contributor(s) |
Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ |
| Citation(s) |
27919753 |
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| Submission date |
Oct 27, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Yoshinobu Igarashi |
| E-mail(s) |
y-igarashi@nibiohn.go.jp
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| Organization name |
National Institutes of Biomedical Innovation, Health and Nutrition
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| Lab |
Toxicogenomics-Informatics Lab
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| Street address |
7-6-8 Asagi-Saito
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| City |
Ibaraki |
| State/province |
Osaka |
| ZIP/Postal code |
567-0085 |
| Country |
Japan |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (40)
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| GSM2362901 |
Advax, id, 6hr, lymph node, biological replicate 1 |
| GSM2362902 |
Advax, id, 6hr, lymph node, biological replicate 2 |
| GSM2362903 |
Vehicle control, id, 6hr, lymph node, biological replicate 1 |
| GSM2362904 |
Vehicle control, id, 6hr, lymph node, biological replicate 2 |
| GSM2362905 |
Advax, id, 6hr, liver, biological replicate 1 |
| GSM2362906 |
Advax, id, 6hr, liver, biological replicate 2 |
| GSM2362907 |
Advax, id, 6hr, liver, biological replicate 3 |
| GSM2362908 |
Vehicle control, id, 6hr, liver, biological replicate 1 |
| GSM2362909 |
Vehicle control, id, 6hr, liver, biological replicate 2 |
| GSM2362910 |
Vehicle control, id, 6hr, liver, biological replicate 3 |
| GSM2362911 |
Advax, id, 6hr, spleen biological replicate 1 |
| GSM2362912 |
Advax, id, 6hr, spleen, biological replicate 2 |
| GSM2362913 |
Advax, id, 6hr, spleen, biological replicate 3 |
| GSM2362914 |
Vehicle control, id, 6hr, spleen, biological replicate 1 |
| GSM2362915 |
Vehicle control, id, 6hr, spleen, biological replicate 2 |
| GSM2362916 |
Vehicle control, id, 6hr, spleen, biological replicate 3 |
| GSM2362917 |
Advax, ip, 6hr, kidney biological replicate 1 |
| GSM2362918 |
Advax, ip, 6hr, kidney, biological replicate 2 |
| GSM2362919 |
Advax, ip, 6hr, kidney, biological replicate 3 |
| GSM2362920 |
Vehicle control, ip, 6hr, kidney, biological replicate 1 |
| GSM2362921 |
Vehicle control, ip, 6hr, kidney, biological replicate 2 |
| GSM2362922 |
Vehicle control, ip, 6hr, kidney, biological replicate 3 |
| GSM2362923 |
Advax, ip, 6hr, lung biological replicate 1 |
| GSM2362924 |
Advax, ip, 6hr, lung, biological replicate 2 |
| GSM2362925 |
Advax, ip, 6hr, lung, biological replicate 3 |
| GSM2362926 |
Vehicle control, ip, 6hr, lung, biological replicate 1 |
| GSM2362927 |
Vehicle control, ip, 6hr, lung, biological replicate 2 |
| GSM2362928 |
Vehicle control, ip, 6hr, lung, biological replicate 3 |
| GSM2362929 |
Advax, ip, 6hr, liver biological replicate 1 |
| GSM2362930 |
Advax, ip, 6hr, liver, biological replicate 2 |
| GSM2362931 |
Advax, ip, 6hr, liver, biological replicate 3 |
| GSM2362932 |
Vehicle control, ip, 6hr, liver, biological replicate 1 |
| GSM2362933 |
Vehicle control, ip, 6hr, liver, biological replicate 2 |
| GSM2362934 |
Vehicle control, ip, 6hr, liver, biological replicate 3 |
| GSM2362935 |
Advax, ip, 6hr, spleen biological replicate 1 |
| GSM2362936 |
Advax, ip, 6hr, spleen, biological replicate 2 |
| GSM2362937 |
Advax, ip, 6hr, spleen, biological replicate 3 |
| GSM2362938 |
Vehicle control, ip, 6hr, spleen, biological replicate 1 |
| GSM2362939 |
Vehicle control, ip, 6hr, spleen, biological replicate 2 |
| GSM2362940 |
Vehicle control, ip, 6hr, spleen, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA350829 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE89249_RAW.tar |
140.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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