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| Status |
Public on Feb 09, 2017 |
| Title |
Peripheral self-reactivity regulates antigen-specific CD8 T cell responses and cell division under physiological conditions |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
It is unknown how naïve CD8 T cells that harbour different and distinct T cell receptors to the same MHC-epitope combination differ in terms of their transcriptional expression profile.
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| Overall design |
In this experiment we compared the expression profile of three naïve transnuclear CD8 T cell clones that differ in their T cell receptor and affinity to cognate peptide and self-reactivity. We find that the transcriptomes of these T cells differ with respect to readiness for cell cycle progression and T cell receptor signaling.
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| |
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| Contributor(s) |
Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel E, Ploegha HL |
| Citation(s) |
27881740 |
| |
| Submission date |
Oct 20, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Eva Frickel |
| E-mail(s) |
eva.frickel@crick.ac.uk
|
| Organization name |
The Francis Crick Institute
|
| Department |
Host-Toxoplasma Interaction Laboratory
|
| Street address |
1 Midland Road
|
| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA349472 |
| SRA |
SRP091872 |
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