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Series GSE88730 Query DataSets for GSE88730
Status Public on Oct 01, 2018
Title Therapeutic effects of Tie2 activation in treatment of neovascular age-related macular degeneration over conventional VEGF blockade.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To investigate a potential therapeutic effect of ABTAA on NV-AMD, we employed a mouse model of laser-induced CNV, that mimics human NV-AMD. A laser photocoagulation on mouse retinas was performed to rupture RPE and Bruch’s membrane, and then the effects of ABTAA were compared with those of VEGF-Trap.
Overall design RPE-choroidal complex was obtained from enucleated eyes and flat-mounted on polyethylene naphthalate membrane (Carl Zeiss). CNV and surrounding tissues (a two-fold larger diameter than CNV itself), including RPE and choroid, were collected using laser capture microdissection (PALM MicroBeam, Carl Zeiss) and subjected to RNA isolation.
Contributor(s) Koh GY, Bae H
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Submission date Oct 14, 2016
Last update date May 15, 2019
Contact name Gou Young Koh
Organization name IBS-KAIST Center for Vascular Research
Department Institue for Basic Science
Street address Room 6101, Biomedical Research Center, E7, KAIST 291, Daehak-ro, Yuseong-gu
City Daejeon
ZIP/Postal code 34141
Country South Korea
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (9)
GSM2344880 Fc Treated_1
GSM2344881 Fc Treated_2
GSM2344882 Fc Treated_3
BioProject PRJNA348410
SRA SRP091537

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE88730_RAW.tar 880.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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