|
| Status |
Public on Nov 28, 2016 |
| Title |
DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
A subset of genomically silent childhood posterior fossa ependymomas show reduced H3K27me3, global DNA hypomethylation, are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin.
|
| |
|
| Overall design |
Quantification of CpG methylation in 3 ependymoma subtypes
|
| |
|
| Contributor(s) |
Mukherjee P, Venneti S |
| Citation(s) |
27881822 |
| |
| Submission date |
Oct 10, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Piali Mukherjee |
| E-mail(s) |
pim2001@med.cornell.edu
|
| Organization name |
Weill Cornell Medicine
|
| Department |
Medicine
|
| Lab |
Epigenomics Core
|
| Street address |
1300 York Ave. C-545
|
| City |
NEW YORK |
| State/province |
New York |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA347565 |
| SRA |
SRP091332 |
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