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| Status |
Public on Jul 05, 2019 |
| Title |
Gene expression of human T cells stimulated in the presence of TGF-β |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine that dictates T-cell fates in various settings. Despite a wealth of data implicating TGF-β in the differentiation and homeostasis of both suppressive and inflammatory T cells, little is known about the role of TGF-β signaling in the development of memory T cells. This experiment was to correlate gene expression with the finding that TGF-β exposure during human T-cell stimulation ex vivo leads to the accumulation of T cells with central memory (tcm) markers.
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| Overall design |
Gene expression quantification of TGF-β-treated (n=4) or untreated (n=3) CD4 and CD8 T cells was generated by deep sequencing, using Ion AmpliSeq™ Transcriptome Human Gene Expression Kit.
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| Contributor(s) |
Dahmani A, Janelle V, Delisle J |
| Citation(s) |
31308016 |
| |
| Submission date |
Sep 30, 2016 |
| Last update date |
Oct 06, 2019 |
| Contact name |
Jean-Sebastien Delisle |
| Organization name |
Centre de recherche de l’Hôpital Maisonneuve-Rosemont
|
| Street address |
5415, boulevard de l’Assomption
|
| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H1T 2M4 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA344972 |
| SRA |
SRP090680 |
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