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Series GSE87508 Query DataSets for GSE87508
Status Public on Jul 05, 2019
Title Gene expression of human T cells stimulated in the presence of TGF-β
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine that dictates T-cell fates in various settings. Despite a wealth of data implicating TGF-β in the differentiation and homeostasis of both suppressive and inflammatory T cells, little is known about the role of TGF-β signaling in the development of memory T cells. This experiment was to correlate gene expression with the finding that TGF-β exposure during human T-cell stimulation ex vivo leads to the accumulation of T cells with central memory (tcm) markers.
Overall design Gene expression quantification of TGF-β-treated (n=4) or untreated (n=3) CD4 and CD8 T cells was generated by deep sequencing, using Ion AmpliSeq™ Transcriptome Human Gene Expression Kit.
Contributor(s) Dahmani A, Janelle V, Delisle J
Citation(s) 31308016
Submission date Sep 30, 2016
Last update date Oct 06, 2019
Contact name Jean-Sebastien Delisle
Organization name Centre de recherche de l’Hôpital Maisonneuve-Rosemont
Street address 5415, boulevard de l’Assomption
City Montreal
State/province Quebec
ZIP/Postal code H1T 2M4
Country Canada
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (14)
GSM2332906 N2_CD4
GSM2332907 N3_CD4
GSM2332908 N4_CD4
BioProject PRJNA344972
SRA SRP090680

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Supplementary file Size Download File type/resource
GSE87508_CD4_normalized.txt.gz 1.5 Mb (ftp)(http) TXT
GSE87508_CD4_rawcounts.txt.gz 228.5 Kb (ftp)(http) TXT
GSE87508_CD8_normalized.txt.gz 1.5 Mb (ftp)(http) TXT
GSE87508_CD8_rawcounts.txt.gz 228.0 Kb (ftp)(http) TXT
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Processed data are available on Series record
Raw data are available in SRA

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