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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 11, 2008 |
| Title |
Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatment. Their gene expression responses between 4 to 12 hr after treatment showed a common set of early gene expression changes indicative of a UPR/Inflammation stress response.
Keywords: control/treatment time course
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| Overall design |
Mouse 3T3-L1 RNA for each time point was isolated from control and treatment samples for analysis on microarrays with two biological reps.
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| Contributor(s) |
LaRosa C, Riethoven JM, Chen H, Xia Y, Zhou Y, Chen M, Miner J, Fromm ME |
| Citation(s) |
17878318 |
| Submission date |
Aug 03, 2007 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jean-Jack M. Riethoven |
| E-mail(s) |
jeanjack@unl.edu
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| Organization name |
University of Nebraska-Lincoln
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| Department |
Beadle Center for Biotechnology
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| Lab |
Bioinformatics Core Research Facility
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| Street address |
1901 Vine Street
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| City |
Lincoln |
| State/province |
NE |
| ZIP/Postal code |
68588-0665 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (8)
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| GSM215285 |
3T3-L1 adipocyte tissue culture, control, T1, biological rep1 |
| GSM215286 |
3T3-L1 adipocyte tissue culture, tunicamycin exposed, T1, biological rep1 |
| GSM215287 |
3T3-L1 adipocyte tissue culture, control, T2, biological rep1 |
| GSM215288 |
3T3-L1 adipocyte tissue culture, control, T2, biological rep2 |
| GSM215289 |
3T3-L1 adipocyte tissue culture, tunicamycin exposed, T2, biological rep1 |
| GSM215290 |
3T3-L1 adipocyte tissue culture, control, T3, biological rep1 |
| GSM215291 |
3T3-L1 adipocyte tissue culture, tunicamycin exposed, T3, biological rep1 |
| GSM215292 |
3T3-L1 adipocyte tissue culture, tunicamycin exposed, T3, biological rep2 |
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| This SubSeries is part of SuperSeries: |
| GSE11384 |
Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes |
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| Relations |
| BioProject |
PRJNA109035 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8682_12hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8682_4hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8682_8hr_RosettaResolver_processed_ratio.xls |
3.0 Mb |
(ftp)(http) |
XLS |
| GSE8682_RAW.tar |
27.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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