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| Status |
Public on Sep 07, 2019 |
| Title |
Exposure to a low-dose pollutant mixture does not trigger obesity in female mice but results in metabolic disturbances showing both common and specific features as compared to a high-fat diet challenge |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In order to identify pollutants effects on liver metabolism in mice, 12 weeks old female mice were submitted to 3 differents diets. Either a standard diet or a high fat diet containing or not a mixture of 4 pollutants. Mice were fed with these diets from preconception to 12 weeks old. Mice were sacrificed and livers were taken and immediately snap frozen until further processing. Microarrays analysis were performed in order to identify direct pollutants effects.
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| Overall design |
12 weeks old female mice were submitted to 3 differents diets. Either a standard diet (ST) or a high fat diet (HFHS) containing (+ pollutants) or not (+ vehicule) a mixture of 4 pollutants.
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| Contributor(s) |
Labaronne E, Meugnier E, Pesenti S, Le magueresse B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 08, 2016 |
| Last update date |
Sep 08, 2019 |
| Contact name |
emmanuelle meugnier |
| E-mail(s) |
meugnier@univ-lyon1.fr
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| Organization name |
INSERMU1060/INRA1397
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| Lab |
CarMeN
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| Street address |
Cens Eli Bat 2 D- Hopital Lyon Sud
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| City |
Pierre Bénite |
| ZIP/Postal code |
69495 |
| Country |
France |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (13)
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| GSM2306294 |
Liver from HFHS diet+ vehicule, biological replicate #1 |
| GSM2306295 |
Liver from HFHS diet+ vehicule, biological replicate #2 |
| GSM2306296 |
Liver from HFHS diet+ vehicule, biological replicate #3 |
| GSM2306297 |
Liver from HFHS diet+ vehicule, biological replicate #4 |
| GSM2306298 |
Liver from HFHS diet+ vehicule, biological replicate #5 |
| GSM2306299 |
Liver from ST diet + vehicule, biological replicate #1 |
| GSM2306300 |
Liver from ST diet + vehicule, biological replicate #2 |
| GSM2306301 |
Liver from ST diet + vehicule, biological replicate #3 |
| GSM2306302 |
Liver from ST diet + pollutants, biological replicate #1 |
| GSM2306303 |
Liver from ST diet + pollutants, biological replicate #2 |
| GSM2306304 |
Liver from ST diet + pollutants, biological replicate #3 |
| GSM2306305 |
Liver from ST diet + pollutants, biological replicate #4 |
| GSM2306306 |
Liver from ST diet + pollutants, biological replicate #5 |
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| Relations |
| BioProject |
PRJNA342306 |
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