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Series GSE85912 Query DataSets for GSE85912
Status Public on Jun 27, 2018
Title Gender and strain dependent differences in intestinal immunology correlate with differences in microbiota composition (ileum)
Organism Mus musculus
Experiment type Expression profiling by array
Summary A dysbiosis in the intestinal microbiome plays a role in the pathogenesis of several immunological diseases. These diseases often show a gender bias, suggesting gender differences in immune responses and in the intestinal microbiome. We hypothesized that gender differences in immune responses are associated with gender differences in microbiota. We demonstrated mouse strain dependent gender differences in the intestinal microbiome. Interestingly, a cluster of colonic genes (related to humoral and cell-mediated immune responses) correlated oppositely with microbiota species abundant in B6 females and in BALB/c males. This suggests that with different genetic backgrounds, gender associated immune responses are differentially regulated by microbiota. The net result was the same, since both mouse strains showed similar gender induced differences in immune cell populations in the mesenteric lymph nodes. Therefore, host-microbe interactions might be more complicated than assumed, as bacterial-species adaptations might be highly dependent on the genetic make-up of the individual.
Overall design Male and female wild-type B6 and BALB/c mice were sacrificed by cervical dislocation between an age of 3 and 5 months. Approximately 1 cm of distal ileum was removed for microarray analysis
Contributor(s) Elderman M, Hugenholtz F, Belzer C, Boekschoten M, van Beek A, de Haan B, Savelkoul H, de Vos P, Faas M
Citation(s) 29914546
Submission date Aug 22, 2016
Last update date Jun 27, 2018
Contact name Guido Hooiveld
Organization name Wageningen University
Department Div. Human Nutrition & Health
Lab Nutrition, Metabolism & Genomics Group
Street address HELIX, Stippeneng 4
City Wageningen
ZIP/Postal code NL-6708WE
Country Netherlands
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (16)
GSM2287225 Ileum_Balb/c_female_repl1
GSM2287226 Ileum_Balb/c_male_repl1
GSM2287227 Ileum_Balb/c_female_repl2
This SubSeries is part of SuperSeries:
GSE85913 Gender and strain dependent differences in intestinal immunology correlate with differences in microbiota composition
BioProject PRJNA339743

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85912_RAW.tar 75.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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