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Series GSE85610 Query DataSets for GSE85610
Status Public on Feb 05, 2019
Title Gene expression profiles in response to proanthocyanidins in pancreatic cancer cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Proanthocyanidins (PAs) that are naturally occurring compounds have shown the potential chemopreventive efficacy against various forms of cancers in different tumor models. To elucidate the responsible molecular mechanisms involved in antitumor therapeutic effects of PAs, the transcriptome changes of pancreatic cancer cells exposure to PAs at 3, 12 and 24h were investigated in this study. Through two biological replicate sequencing, 966, 3543 and 4944 differentially expressed genes in response to PAs exposure were detected at 3, 12 and 24h, respectively. GO and KEGG analysis showed that cell cycle checkpoints and DNA repair modulations or inhibition were the mainly mechanisms in PAs anti-cancer. Overall, this study provided novel insights into not only the first integrated overview on global gene expression in pancreatic cancer cells post PAs exposure, but also the underlying mechanisms of anti-cancer effects of PAs for chemotherapy.
Overall design Transcriptome change of PANC-1 cells post Proanthocyanidins (20 μg/ml) exposure at 3, 12 and 24h were investigated. A biological replicate sequencing was carried out.
Contributor(s) Zhang Y
Citation(s) 30675233, 30854052
Submission date Aug 15, 2016
Last update date May 15, 2019
Contact name Dong Chen
Organization name ABLife, Inc.
Department Center for Genome Analysis
Street address 388 GaoXin 2nd Road, East Lake Hi-Tech Development Zone
City Wuhan
State/province Hubei
ZIP/Postal code 430075
Country China
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (14)
GSM2279678 PAs-C1-0h
GSM2279679 PAs-C2-0h
GSM2279680 PAs-C1-3h
BioProject PRJNA338947
SRA SRP082152

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Supplementary file Size Download File type/resource
GSE85610_expressed_gene_RPKM.txt.gz 1017.4 Kb (ftp)(http) TXT
GSE85610_expressed_gene_reads.txt.gz 1.0 Mb (ftp)(http) TXT
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Processed data are available on Series record

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