|
| Status |
Public on Nov 22, 2017 |
| Title |
Methylation and expression profiles of monocytes in monozygotic twins: role in Myasthenia Gravis [expression profiling] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Myasthenia gravis (MG) is a relatively rare autoimmune neuromuscular disorder. Monozygotic twin studies indicate that discordance rate in MG is about 70-60%, suggesting that despite identical DNA unknown factors contribute to disease development. The aim of the current study was to identify novel disease-associated genes in purified monocytes, including both genes associated with predisposition or with disease course, using the unique model of MZ twins. Thus the transcriptome and methylome were compared between twins discordant and concordant for the diseases, as well as MG singletons, and healthy controls. Several transcripts associated with immune homeostasis and inflammation resolution were highlighted in the current study. High similarity between the healthy and the MG discordant twins found, suggest that genetic predisposition may have a stronger contribution then previously assumed. In addition, results suggest that numerous small changes in expression and DNA methylation might contribute to disease onset making it more difficult to pick up
|
| |
|
| Overall design |
The transcriptome and methylome were compared between twins discordant and concordant for Maysthenia Gravis, as well as MG singletons, and healthy controls
|
| |
|
| Contributor(s) |
Mamrut S, Avidan N, Truffault F, Staun-Ram E, Frenkian M, Berrih-Aknin S, Miller A |
| Citation(s) |
28549776 |
| |
| Submission date |
Aug 10, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Sonia Berrih-Aknin |
| E-mail(s) |
sonia.berrih-aknin@upmc.fr
|
| Organization name |
UPMC - Inserm UMRS 974, CNRS FRE3617
|
| Department |
Sorbonne Universités
|
| Lab |
Center of Research in Myology
|
| Street address |
105 Boulevard de l’Hôpital
|
| City |
Paris |
| State/province |
State... |
| ZIP/Postal code |
75651 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (25)
|
|
| This SubSeries is part of SuperSeries: |
| GSE85649 |
Methylation and expression profiles of monocytes in monozygotic twins: role in Myasthenia Gravis |
|
| Relations |
| BioProject |
PRJNA338489 |
Less...
More...